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2-(Diethylamino)benzonitrile
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2-(Diethylamino)benzonitrile
Lieferant:
Sigma-Aldrich
Beschreibung:
L(+)-Leucin, Sigma-Aldrich®
Lieferant:
Novus Biologicals
Beschreibung:
The beta-III Tubulin Antibody (2E9) from Novus Biologicals is a mouse monoclonal antibody to beta-III Tubulin. This antibody reacts with human. The beta-III Tubulin Antibody (2E9) has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, ELISA, Immunocytochemistry / Immunofluorescence.
Artikel-Nr:
(BOSSBS-11236R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11236R-HRP
Lokale Artikelnummer::
BOSSBS-11236R-HRP
Beschreibung:
During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
di-Natrium-β-glycerophosphat Pentahydrat 98%
Artikel-Nr:
(PRSI77-031)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-031
Lokale Artikelnummer::
PRSI77-031
Beschreibung:
The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI77-040)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-040
Lokale Artikelnummer::
PRSI77-040
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,5 mg
New Product
Artikel-Nr:
(ABCAAB237983-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB237983-100
Lokale Artikelnummer::
ABCAAB237983-100
Beschreibung:
Anti-beta Catenin Mouse Monoclonal Antibody [clone: rCTNNB1/2173]
VE:
1 * 100 µG
 This is a MarketSource item. Additional charges may apply
Lieferant:
PanReac AppliChem
Beschreibung:
Isopropyl β-D-thiogalactopyranoside (IPTG) is derived from plant origin galactose.
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Acetaminophen β-D-glucuronide ≥95%
Lieferant:
Alfa Aesar
Beschreibung:
2-Naphthoesäure ≥98%
Artikel-Nr:
(BSENS-077-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
S-077-100
Lokale Artikelnummer::
BSENS-077-100
Beschreibung:
Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
VE:
1 * 100 µG
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Acedoben-acyl-β-D-glucuronide ≥98%
Artikel-Nr:
(BOSSBS-5617R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5617R-CY3
Lokale Artikelnummer::
BOSSBS-5617R-CY3
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5617R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5617R-CY5.5
Lokale Artikelnummer::
BOSSBS-5617R-CY5.5
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2225R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2225R
Lokale Artikelnummer::
BOSSBS-2225R
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI90-506)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-506
Lokale Artikelnummer::
PRSI90-506
Beschreibung:
Interleukin-18 (IL-18) is a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesised as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE; Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-gamma also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 have also been reported, such as enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF, IFN-gamma in T cells and enhancement of Fas ligand expression by Th1 cells.
VE:
1 * 10 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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