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Artikel-Nr:
(BOSSBS-5182R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5182R-CY5
Lokale Artikelnummer::
BOSSBS-5182R-CY5
Beschreibung:
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(NOVUNBP1-79952)
Lieferant:
Novus Biologicals
Hersteller-Artikelnummer::
NBP1-79952
Lokale Artikelnummer::
NOVUNBP1-79952
Beschreibung:
Rabbit Polyclonal Nicotinic Acetylcholine Receptor gamma Antibody. Tested Applications: Western Blot. Tested Reactivity: Human, Mouse, Rat, Bovine, Canine.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-2374R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2374R-A488
Lokale Artikelnummer::
BOSSBS-2374R-A488
Beschreibung:
TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3345R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3345R-CY7
Lokale Artikelnummer::
BOSSBS-3345R-CY7
Beschreibung:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylates both ECT2 and RACGAP1, and thereby stimulates their interaction that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2.
VE:
1 * 100 µl
Artikel-Nr:
(ORIGTA130050)
Lieferant:
OriGene
Hersteller-Artikelnummer::
TA130050
Lokale Artikelnummer::
ORIGTA130050
Beschreibung:
Anti-IgG Rabbit gamma Antibody (HRP (Horseradish Peroxidase))
VE:
1 * 1 mg
Artikel-Nr:
(ORIGTA130004)
Lieferant:
OriGene
Hersteller-Artikelnummer::
TA130004
Lokale Artikelnummer::
ORIGTA130004
Beschreibung:
Anti-IgG Goat gamma Antibody (HRP (Horseradish Peroxidase))
VE:
1 * 0,5 mg
Artikel-Nr:
(ORIGTA130023)
Lieferant:
OriGene
Hersteller-Artikelnummer::
TA130023
Lokale Artikelnummer::
ORIGTA130023
Beschreibung:
Anti-IgG Goat gamma Antibody (HRP (Horseradish Peroxidase))
VE:
1 * 0,5 mg
Artikel-Nr:
(ORIGTA130005)
Lieferant:
OriGene
Hersteller-Artikelnummer::
TA130005
Lokale Artikelnummer::
ORIGTA130005
Beschreibung:
Anti-IgG Goat gamma Antibody (HRP (Horseradish Peroxidase))
VE:
1 * 1 mg
Artikel-Nr:
(BOSSBS-5182R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5182R-A647
Lokale Artikelnummer::
BOSSBS-5182R-A647
Beschreibung:
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5182R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5182R-FITC
Lokale Artikelnummer::
BOSSBS-5182R-FITC
Beschreibung:
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI40-590)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-590
Lokale Artikelnummer::
PRSI40-590
Beschreibung:
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
VE:
1 * 10 µG
Artikel-Nr:
(BOSSBS-13644R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13644R-HRP
Lokale Artikelnummer::
BOSSBS-13644R-HRP
Beschreibung:
The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Bromkresolgrün Natriumsalz 0,04% (w/v) in wässriger Lösung
Lieferant:
MP Biomedicals
Beschreibung:
Storage: +4 °C
D-Biotin is a growth factor present in small amounts in every living cell. It is involved in naturally occurring carboxylation reactions. It occurs mainly bound to proteins or polypeptides. It is more abundant in the liver, kidney, pancreas, yeast and milk. Biotin levels are higher in cancerous tumors than in normal tissues. It is inactivated by binding to avidin. D-Biotin may be used to elute proteins from avidin/streptavidin resins. It is widely used for dietary supplements and fortified foods. It is also used for tablets and hard-shell capsule preparation due to its pharmaceutical properties. Essential vitamin that is important for amino acid and energy metabolism, and fatty acid synthesis. It is a prosthetic group in four mammalian carboxylase families and facilitates the binding and transfer of carbon dioxide. Soluble in water (22 mg/100 mL), ethanol (80 mg/100 mL), more soluble in hot water and in dilute alkalies; insoluble in other common organic solvents. Soluble in 2 M Ammonium hydroxide (50 mg/mL - clear, colorless solution), dimethylformamide (1.7 mg/mL).
Artikel-Nr:
(PRSI90-487)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-487
Lokale Artikelnummer::
PRSI90-487
Beschreibung:
Interleukin-6 (IL-6) is a multifunctional factor, which exerts its activities through binding to a highaffinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6Ralpha) and a signal transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for highaffinity binding of IL-6 by the complex. A soluble form of the IL-6Ralpha has been found in the urine of healthy adult humans.
VE:
1 * 50 µG
Artikel-Nr:
(BSBTPB9024)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9024
Lokale Artikelnummer::
BSBTPB9024
Beschreibung:
Polyclonal antibody for INTERFERON GAMMA/IFNG detection. Host: Rabbit.Size: 100μg/vial. Tested applications: ELISA. Reactive species: Rat. INTERFERON GAMMA/IFNG information: Molecular Weight: 17918 MW; Subcellular Localization: Secreted; Tissue Specificity: Released primarily from activated T lymphocytes.
VE:
1 * 100 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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