1,4-Bis(aminomethyl)cyclohexane+(cis+and+trans+mixture)
Artikel-Nr:
(BOSSBS-0483R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0483R-A680
Lokale Artikelnummer::
BOSSBS-0483R-A680
Beschreibung:
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognise specific histone modifications (the 'histone code' hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13345R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13345R-FITC
Lokale Artikelnummer::
BOSSBS-13345R-FITC
Beschreibung:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6216R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-A488
Lokale Artikelnummer::
BOSSBS-6216R-A488
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6216R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-A555
Lokale Artikelnummer::
BOSSBS-6216R-A555
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6216R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-A350
Lokale Artikelnummer::
BOSSBS-6216R-A350
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD234134-50MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD234134-50MG
Lokale Artikelnummer::
BLDPBD234134-50MG
Beschreibung:
6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde 5,5-dioxide 95%
VE:
1 * 50 mg
Lieferant:
Biotium
Beschreibung:
Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Artikel-Nr:
(BOSSBS-11292R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11292R-FITC
Lokale Artikelnummer::
BOSSBS-11292R-FITC
Beschreibung:
The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. HOX genes that occupy the same relative position along the 5’ to 3’ coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent HOX genes on the same chromosome. HoxA3, in conjunction with Pax1, mediates the development of the thymus, parathyroid gland, and carotid body. Its expression in the third pharyngeal arch and pouch is required for development of the third arch artery, and homozygous null HoxA3 mutants lack the carotid body. HoxA3 also regulates hindbrain development by controlling the axon projection pattern of motor neurons and sensory neurons of the proximal and distal ganglia.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3,5-Bis(trifluoromethyl)phenylacetyl chloride 97%
Artikel-Nr:
(BLDPBD634578-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD634578-5G
Lokale Artikelnummer::
BLDPBD634578-5G
Beschreibung:
(2-Ammonioethyl)di-t-butylphosphonium bis(tetrafluoroborate) 98%
VE:
1 * 5 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
1-(Difluoromethyl)-3,5-bis(trifluoromethyl)benzene 97%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Methoxy-4,6-bis(trifluormethyl)benzonitril 98%
Lieferant:
Spectrum Chemical
Beschreibung:
Carmine, also known as cochineal or crimson lake, is a red colored pigment obtained from the aluminum salt of carminic acid. It is used in artificial flowers, paints and coloring. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Artikel-Nr:
(BLDPBD226994-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD226994-250MG
Lokale Artikelnummer::
BLDPBD226994-250MG
Beschreibung:
3,3'-(Methylazanediyl)bis(propan-1-ol) 95+%
VE:
1 * 250 mg
Artikel-Nr:
(BLDPBD284628-25G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD284628-25G
Lokale Artikelnummer::
BLDPBD284628-25G
Beschreibung:
4-Bromo-1,2-bis(trifluoromethyl)benzene 97%
VE:
1 * 25 g
Artikel-Nr:
(BLDPBD315943-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD315943-250MG
Lokale Artikelnummer::
BLDPBD315943-250MG
Beschreibung:
Anthracene-9,10-diboronic acid bis(pinacol) ester 98%
VE:
1 * 250 mg
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
![]()
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
![]()
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||