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POLYMER STANDARDS SERVICE


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Lieferant:  SciLabware
Beschreibung:   PYREX®-Glas, dickwandig.
Lieferant:  FLUOROCHEM
Beschreibung:   1-(4-Methylphenyl)piperazin

Lieferant:  LGC Standards PROMOCHEM
Hersteller-Artikelnummer:: NMIAP1795
Lokale Artikelnummer:: PROONMIAP1795
Beschreibung:   Purity estimate obtained by subtraction from 100% of total impurities by GC-FID, thermogravimetric analysis, Karl Fischer analysis and 1H NMR is 99,1 ± 1,4% mass fraction, (95% coverage interval). Supporting evidence is provided by elemental microanalysis.
VE:  1 * 5 mg

Lieferant:  ProSci Inc.
Hersteller-Artikelnummer:: 92-173
Lokale Artikelnummer:: PRSI92-173
Beschreibung:   Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4(PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, PIN4 protein binds to double-stranded DNA under physiological salt conditions. PIN4 is involved as a ribosomal RNA processing factor in ribosome biogenesis. The PAR14 binds to tightly bent AT-rich stretches of double-stranded DNA, but PAR17 binds to double-stranded DNA.
VE:  1 * 50 µG
Lieferant:  DWK Life Sciences
Beschreibung:   DURAN®, Borosilikatglas 3.3, klar, mit PE-Stopfen, ohne Konformitätsbescheinigung
Artikel-Nr: (BACE4000240.0100)

Lieferant:  BACHEM BIOCHEMICA
Hersteller-Artikelnummer:: 4000240.0100
Lokale Artikelnummer:: BACE4000240.0100
Beschreibung:   N(α)-Boc-L-tryptophan
VE:  1 * 100 g
Market Source Item This is a MarketSource item. Additional charges may apply

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-1135R-A680
Lokale Artikelnummer:: BOSSBS-1135R-A680
Beschreibung:   c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labelling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr --> Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:  1 * 100 µl
Artikel-Nr: (SIAL183199-50G)

Lieferant:  Sigma-Aldrich
Hersteller-Artikelnummer:: 183199-50G
Lokale Artikelnummer:: SIAL183199-50G
Beschreibung:   2',5'-Dichloracetophenon, Sigma-Aldrich®
VE:  1 * 50 g
Lieferant:  COMBI-BLOCKS
Beschreibung:   2-Fluorisonicotinonitril
Artikel-Nr: (BOSSBS-3353R-CY5.5)

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-3353R-CY5.5
Lokale Artikelnummer:: BOSSBS-3353R-CY5.5
Beschreibung:   Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
VE:  1 * 100 µl
Lieferant:  HIRSCHMANN
Beschreibung:   DURAN®, borosilicate glass, amber, with PE stopper, USP certified.
Lieferant:  Alfa Aesar
Beschreibung:   Geldanamycin ≥99%
Lieferant:  GLASWARENFABRIK KARL HECHT
Beschreibung:   Natronkalkglas, klar oder braun, mit Normschliff und Glasstopfen
Lieferant:  WITEG LABORTECHNIK
Beschreibung:   Volumetric flask with ground joint neck made up of made of borosilicate glass 3.3.
Lieferant:  SciLabware
Beschreibung:   PYREX®, Borosilikatglas, mit PE-Stopfen.
Lieferant:  FLUOROCHEM
Beschreibung:   1-Methyl-3-phenylpiperazin
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