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4-(4-Methylpiperazin-1-yl)benzoic+acid
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4-(4-Methylpiperazin-1-yl)benzoic+acid
Artikel-Nr:
(BOSSBS-5004R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5004R-A488
Lokale Artikelnummer::
BOSSBS-5004R-A488
Beschreibung:
PFKFB1 belongs to the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. It forms a homodimer that is involved in both the synthesis and degradation of fructose 2,6-bisphosphate. The activity of this enzyme is thought to regulate glucose homeostasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7057R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7057R-A488
Lokale Artikelnummer::
BOSSBS-7057R-A488
Beschreibung:
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-A555
Lokale Artikelnummer::
BOSSBS-15497R-A555
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7728R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7728R-A750
Lokale Artikelnummer::
BOSSBS-7728R-A750
Beschreibung:
SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7728R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7728R-CY3
Lokale Artikelnummer::
BOSSBS-7728R-CY3
Beschreibung:
SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7728R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7728R-CY5
Lokale Artikelnummer::
BOSSBS-7728R-CY5
Beschreibung:
SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9301R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9301R
Lokale Artikelnummer::
BOSSBS-9301R
Beschreibung:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9301R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9301R-CY7
Lokale Artikelnummer::
BOSSBS-9301R-CY7
Beschreibung:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12335R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12335R-CY5
Lokale Artikelnummer::
BOSSBS-12335R-CY5
Beschreibung:
The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
VE:
1 * 100 µl
Artikel-Nr:
(ROCK113-4139)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
113-4139
Lokale Artikelnummer::
ROCK113-4139
Beschreibung:
Anti-Sheep Red Blood Cell Antibody may be used in hemagglutination assays. Haemagglutination assay or HA is a method of quantification for viruses or bacteria by hemagglutination. Some viral families and many bacteria have envelope or surface proteins which are able to agglutinate (stick to) human or animal red blood cells (RBC) and bind to N-acetylneuraminic acid. As each of the agglutinating molecule attaches to multiple RBCs, a lattice-structure will form. Normally, a virus dilution (e.g. 2-fold from 1:4 to 1:4096) will be applied to an RBC dilution (e.g. 0.1% to 0.7% in steps of 0.2%) for approx. 30 min, often at 4° C, otherwise viruses with neuraminidase activity will detach the virus from the RBCs. Then the lattice forming parts will be counted and the titer calculated. The titer of a hemagglutination assay is determined by the last viable "lattice" structure found. This is because it is at the point where, if diluted anymore, the amount of Virus particles will be less than that of the RBCs and thus not be able to agglutinate them together. Anti-SHEEP Red Blood Cell Antibody is used to sensitize erythrocytes and quantitate agglutination.
VE:
1 * 2 mL
Artikel-Nr:
(BOSSBS-9338R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9338R-CY5
Lokale Artikelnummer::
BOSSBS-9338R-CY5
Beschreibung:
MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9338R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9338R-CY5.5
Lokale Artikelnummer::
BOSSBS-9338R-CY5.5
Beschreibung:
MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-16920R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-16920R-A680
Lokale Artikelnummer::
BOSSBS-16920R-A680
Beschreibung:
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5089R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5089R-A555
Lokale Artikelnummer::
BOSSBS-5089R-A555
Beschreibung:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5089R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5089R-A488
Lokale Artikelnummer::
BOSSBS-5089R-A488
Beschreibung:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2723R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2723R-A647
Lokale Artikelnummer::
BOSSBS-2723R-A647
Beschreibung:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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