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6-Ethynyl-1H-pyrazolo[4,3-c]pyridine
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6-Ethynyl-1H-pyrazolo[4,3-c]pyridine
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Artikel-Nr:
(BOSSBS-11231R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11231R
Lokale Artikelnummer::
BOSSBS-11231R
Beschreibung:
RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11231R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11231R-CY5
Lokale Artikelnummer::
BOSSBS-11231R-CY5
Beschreibung:
RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11339R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11339R-A680
Lokale Artikelnummer::
BOSSBS-11339R-A680
Beschreibung:
Members of the calsyntenin protein family are localised to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-2, also known as Alcadein-gamma, is a 955 amino acid protein that localizes to the endoplasmic reticulum, golgi apparatus and plasma membranes. Containing 2 cadherin-like repeats in its N-terminal extracellular region, calsyntenin-2 binds synaptic calcium with its cytoplasmic domain, suggesting a role in the modulation of calcium-mediated postsynaptic signals. Under normal physiological conditions, calsyntenin-2 is protoeolytically processed in an event in which the primary zeta-cleavage generates a short C-terminal transmembrane fragment and a long extracellular N-terminal domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7552R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7552R-A488
Lokale Artikelnummer::
BOSSBS-7552R-A488
Beschreibung:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3943R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3943R-A555
Lokale Artikelnummer::
BOSSBS-3943R-A555
Beschreibung:
G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2621R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2621R-A350
Lokale Artikelnummer::
BOSSBS-2621R-A350
Beschreibung:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
VE:
1 * 100 µl
Lieferant:
CONTEC
Beschreibung:
Diese nicht pyrogenen Wischtücher sind die ersten speziell für die Pharma-, Medizinprodukt- und Biotechnologiebranche entwickelten sterilen Vliestücher. Hergestellt aus Sontara® Lyocell/Polyester-Vliesmaterial verfügen diese Tücher über einen sehr niedrigen Endotoxin-Gehalt und eine exzellente Saugfähigkeit.Verpackt, gamma-sterilisiert und validiert auf 10⁻⁶SAL.
Artikel-Nr:
(BOSSBS-0400R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0400R-A680
Lokale Artikelnummer::
BOSSBS-0400R-A680
Beschreibung:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10462R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10462R-A488
Lokale Artikelnummer::
BOSSBS-10462R-A488
Beschreibung:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6894R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6894R-A350
Lokale Artikelnummer::
BOSSBS-6894R-A350
Beschreibung:
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0503R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0503R-A350
Lokale Artikelnummer::
BOSSBS-0503R-A350
Beschreibung:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6894R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6894R-FITC
Lokale Artikelnummer::
BOSSBS-6894R-FITC
Beschreibung:
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12153R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12153R-A750
Lokale Artikelnummer::
BOSSBS-12153R-A750
Beschreibung:
Beta-taxilin promotes nerve regeneration and may be involved in intracellular vesicle transport. Expressed predominantly in cardiac and skeletal muscle, beta-taxilin binds to the coiled coil region of the syntaxin family members STX1A, STX3A, and STX4A. Beta- and gamma-taxilins, bind to the alpha subunit of the nascent polypeptide-associated complex (NAC) and affect its nuclear distribution, suggesting that the taxilin family is involved not only in the translational process through its interaction with NAC but also in the transcriptional process through its interaction with alphaNAC alone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1350R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1350R-A680
Lokale Artikelnummer::
BOSSBS-1350R-A680
Beschreibung:
Death Associated Protein 5 (DAP5) is a 97 kDa protein with high amino acid sequence homology to Eukaryotic Translation Initiation Factor 4G (eIF4G). Compared with eIF4G, DAP5 lacks the N-terminal region necessary for cap-dependent translation and has a unique C-terminal part functioning as a regulator for interferon-gamma induced cell death. During apoptosis, DAP5 is cleaved at Asp790. The C-terminal truncated form of DAP5 functions as a cap-independent translation initiation factor responsible for the mediation of its own translation during apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0503R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0503R-CY7
Lokale Artikelnummer::
BOSSBS-0503R-CY7
Beschreibung:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12420R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12420R-FITC
Lokale Artikelnummer::
BOSSBS-12420R-FITC
Beschreibung:
14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca (2+)/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell signaling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family.This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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