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6-Fluorobenzo[d]isoxazol-3(2H)-one
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6-Fluorobenzo[d]isoxazol-3(2H)-one
Artikel-Nr:
(BOSSBS-11277R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-CY3
Lokale Artikelnummer::
BOSSBS-11277R-CY3
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(228710-500G)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
228710-500G
Lokale Artikelnummer::
HONC228710-500G
Beschreibung:
Nitroprussid-Natrium Dihydrat ≥99% ACS, Fluka™
VE:
1 * 500 g
Lieferant:
Thermo Scientific
Beschreibung:
Nitroprussid-Natrium Dihydrat ACS, erfüllt analytische Spezifikationen von Reagent Ph. Eur.
Lieferant:
HUBER
Beschreibung:
Unistat® Geräte sind die ideale Lösung für die schnelle und präzise Temperaturregelung von extern angeschlossenen Systemen. Diese kompakten Geräte ermöglichen eine bisher nicht erreichbare Leistung, eine schnelle Temperaturänderung und den Einsatz über einen breiten Temperaturbereich, ohne dass die Flüssigkeit ausgetauscht werden muss. Es stehen über 60 Modelle, z. B. in einem eleganten Desktop-Gehäuse oder in einem flachen Design, mit Kühlleistungen von 0,7 bis 130 kW, zur Auswahl. Unistat® Geräte bieten für alle Anwendungen ein professionelles Scale-up, da vom Entwicklungslabor bis zu den Produktionssystemen dieselben stabilen Prozessbedingungen gelten. Die Einheiten verfügen über eine Reihe von Sicherheitsfunktionen, bieten eine flexible Kommunikation über USB- und LAN-Schnittstellen und bieten umfassende Alarme. Die Geräte sind ideal zur Verwendung mit Reaktorsystemen, Autoklaven, Pilot- und Kleinanlagen, Scale-up-Entwicklungen, doppelwandigen Reaktionsgefäßen, Destillationssystemen und Materialprüfungen, sowie zum Einsatz in der kombinatorischen Chemie und der Halbleiterindustrie geeignet.
Artikel-Nr:
(BOSSBS-13373R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13373R-A750
Lokale Artikelnummer::
BOSSBS-13373R-A750
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-4, also known as HKR4, is a 376 amino acid protein that localizes to the nucleus and contains seven C2H2-type zinc fingers. Belonging to the krueppel C2H2-type zinc-finger protein family, GLI-4 may function as a transcriptional regulator, effectively activating or repressing the transcription of target genes. The gene encoding GLI-4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9186R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9186R-A680
Lokale Artikelnummer::
BOSSBS-9186R-A680
Beschreibung:
SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart diseaseall symptoms of HSCR.
VE:
1 * 100 µl
Artikel-Nr:
(234610-500)
Lieferant:
Merck Millipore (Calbiochem)
Hersteller-Artikelnummer::
234610-500
Lokale Artikelnummer::
CALB234610-500
Beschreibung:
Kongorot, Sigma-Aldrich®
VE:
1 * 500 mg
Artikel-Nr:
(MFLX07115-97)
Lieferant:
Avantor Fluid Handling
Hersteller-Artikelnummer::
07115-97
Lokale Artikelnummer::
MFLB07115-97
Beschreibung:
Make the most of your Masterflex® piston pumps with these accessories.
VE:
1 * 1 ST
Artikel-Nr:
(1724736.)
Lieferant:
USP
Hersteller-Artikelnummer::
1724736
Lokale Artikelnummer::
USPH1724736
Beschreibung:
USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
VE:
1 * 100 mg
Artikel-Nr:
(BOSSBS-9162R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9162R-A680
Lokale Artikelnummer::
BOSSBS-9162R-A680
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterised by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM17 (tripartite motif-containing 17), also known as RBCC, terf or RNF16, is a 477 amino acid protein that contains one RING-type zinc finger, one SPRY domain and one B box-type zinc finger. Expressed nearly exclusively in testis, TRIM17 belongs to the TRIM family and, based on its functional domains, may play a role in transcriptional regulation events. The gene encoding TRIM17 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson?s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9162R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9162R-A647
Lokale Artikelnummer::
BOSSBS-9162R-A647
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM17 (tripartite motif-containing 17), also known as RBCC, terf or RNF16, is a 477 amino acid protein that contains one RING-type zinc finger, one SPRY domain and one B box-type zinc finger. Expressed nearly exclusively in testis, TRIM17 belongs to the TRIM family and, based on its functional domains, may play a role in transcriptional regulation events. The gene encoding TRIM17 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9245R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9245R-A488
Lokale Artikelnummer::
BOSSBS-9245R-A488
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH10 (membrane-associated ring finger (C3HC4) 10), also known as RNF190 (ring finger protein 190) or MARCH-X, is an 808 amino acid protein with one RING-CH-type zinc finger domain. MARCH10 may function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11277R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-A488
Lokale Artikelnummer::
BOSSBS-11277R-A488
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-HRP
Lokale Artikelnummer::
BOSSBS-15486R-HRP
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-FITC
Lokale Artikelnummer::
BOSSBS-15486R-FITC
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9152R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9152R-CY3
Lokale Artikelnummer::
BOSSBS-9152R-CY3
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM50 (tripartite motif containing 50), also known as TRIM50A or E3 ubiquitin-protein ligase TRIM50, is a 487 amino acid cytoplasmic protein that functions as an E3 ubiquitin-protein ligase. Containing one RING-type zinc finger, a B30.2/SPRY domain and a single B box-type zinc finger, TRIM50 belongs to the TRIM/RBCC family and undergoes post-translational auto-ubiquitination. TRIM50 exists as two alternatively spliced isoforms, designated TRIM50 alpha and TRIM50 beta, and has the ability to form dimers and trimers. The gene encoding TRIM50 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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