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1-(2-Cyanophenyl)-4-piperidinecarboxylic+acid
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1-(2-Cyanophenyl)-4-piperidinecarboxylic+acid
Artikel-Nr:
(PRSI77-040)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-040
Lokale Artikelnummer::
PRSI77-040
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,5 mg
New Product
Lieferant:
PanReac AppliChem
Beschreibung:
Isopropyl β-D-thiogalactopyranoside (IPTG) is derived from plant origin galactose.
Artikel-Nr:
(BSENS-077-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
S-077-100
Lokale Artikelnummer::
BSENS-077-100
Beschreibung:
Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
VE:
1 * 100 µG
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Acedoben-acyl-β-D-glucuronide ≥98%
Artikel-Nr:
(BSENR-056-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-056-100
Lokale Artikelnummer::
BSENR-056-100
Beschreibung:
Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects nerurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5617R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5617R-CY3
Lokale Artikelnummer::
BOSSBS-5617R-CY3
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5617R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5617R-CY5.5
Lokale Artikelnummer::
BOSSBS-5617R-CY5.5
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2225R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2225R
Lokale Artikelnummer::
BOSSBS-2225R
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI90-506)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-506
Lokale Artikelnummer::
PRSI90-506
Beschreibung:
Interleukin-18 (IL-18) is a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesised as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE; Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-gamma also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 have also been reported, such as enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF, IFN-gamma in T cells and enhancement of Fas ligand expression by Th1 cells.
VE:
1 * 10 µG
Artikel-Nr:
(ABCAAB206872-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB206872-100
Lokale Artikelnummer::
ABCAAB206872-100
Beschreibung:
Anti-PDGFR alpha+PDGFR beta Rabbit Monoclonal Antibody [clone: Y92] (Alexa Fluor® 594)
VE:
1 * 100 µl
 This is a MarketSource item. Additional charges may apply
Lieferant:
Corning Life Science
Beschreibung:
FBS is a commonly used cell culture media supplement which helps sustain cell growth and satisfy metabolic requirements.
Lieferant:
Alfa Aesar
Beschreibung:
2-Naphthoesäure ≥98%
Lieferant:
Alfa Aesar
Beschreibung:
α,α,α',α'-Tetrafluor-p-xylol ≥98%
Artikel-Nr:
(BOSSBS-9548R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9548R
Lokale Artikelnummer::
BOSSBS-9548R
Beschreibung:
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical Alpha and beta subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The beta subunit, which is known as FT beta, CAAX farnesyltransferase subunit beta, or Ras proteins prenyltransferase subunit beta, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The Alpha subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9548R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9548R-CY7
Lokale Artikelnummer::
BOSSBS-9548R-CY7
Beschreibung:
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical Alpha and beta subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The beta subunit, which is known as FT beta, CAAX farnesyltransferase subunit beta, or Ras proteins prenyltransferase subunit beta, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The Alpha subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0641R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0641R-CY7
Lokale Artikelnummer::
BOSSBS-0641R-CY7
Beschreibung:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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