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(\u00B1)11(12)-EET+methyl+ester
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(\u00B1)11(12)-EET+methyl+ester
Lieferant:
Cytiva
Beschreibung:
The microcarrier of choice for cells that are difficult to culture<i> in vitro</i> - particularly for cells with an epithelial-like morphology.
Artikel-Nr:
(BOSSBS-4286R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4286R-CY5.5
Lokale Artikelnummer::
BOSSBS-4286R-CY5.5
Beschreibung:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
VE:
1 * 100 µl
Artikel-Nr:
(ABCAAB312771-100UL)
Lieferant:
Abcam
Beschreibung:
Anti-DNA Polymerase beta Rabbit Monoclonal Antibody [clone: EPR12722(B)] (Alexa Fluor® 568)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10368R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10368R
Lokale Artikelnummer::
BOSSBS-10368R
Beschreibung:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
VE:
1 * 100 µl
Artikel-Nr:
(USBI168254)
Lieferant:
US Biological
Hersteller-Artikelnummer::
168254
Lokale Artikelnummer::
USBI168254
Beschreibung:
Anti-IFN-B Rabbit Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(BSBTPA1582)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PA1582
Lokale Artikelnummer::
BSBTPA1582
Beschreibung:
Rabbit IgG polyclonal antibody for Laminin subunit gamma-2(LAMC2) detection. Tested with WB, IHC-P in Human; Mouse; Rat.
VE:
1 * 0,1 mg
Artikel-Nr:
(BOSSBS-10368R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10368R-HRP
Lokale Artikelnummer::
BOSSBS-10368R-HRP
Beschreibung:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10368R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10368R-A647
Lokale Artikelnummer::
BOSSBS-10368R-A647
Beschreibung:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
VE:
1 * 100 µl
Lieferant:
BIOMOL RESEARCH LABORATORIES
Beschreibung:
Octyl-β-D-thioglucopyranosid
Artikel-Nr:
(BLDPBD18991-25G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD18991-25G
Lokale Artikelnummer::
BLDPBD18991-25G
Beschreibung:
2-Chlor-3-picolin 97%
VE:
1 * 25 g
Artikel-Nr:
(BOSSBS-4135R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4135R
Lokale Artikelnummer::
BOSSBS-4135R
Beschreibung:
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Isonicotinamid, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-12862R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12862R-A750
Lokale Artikelnummer::
BOSSBS-12862R-A750
Beschreibung:
The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
VE:
1 * 100 µl
Lieferant:
Abcam
Beschreibung:
Anti-TGF beta Receptor II Rabbit Monoclonal Antibody [clone: EPR23148-264]
Artikel-Nr:
(BOSSBS-1361R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1361R-CY3
Lokale Artikelnummer::
BOSSBS-1361R-CY3
Beschreibung:
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF1B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1736R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1736R-HRP
Lokale Artikelnummer::
BOSSBS-1736R-HRP
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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