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2-[Benzyl(2-hydroxyethyl)amino]-1-ethanol
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2-[Benzyl(2-hydroxyethyl)amino]-1-ethanol
Artikel-Nr:
(BOSSBS-3423R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-A647
Lokale Artikelnummer::
BOSSBS-3423R-A647
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3384R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3384R-A647
Lokale Artikelnummer::
BOSSBS-3384R-A647
Beschreibung:
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2793R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2793R-A647
Lokale Artikelnummer::
BOSSBS-2793R-A647
Beschreibung:
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6703R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6703R-A750
Lokale Artikelnummer::
BOSSBS-6703R-A750
Beschreibung:
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialised endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI90-235)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-235
Lokale Artikelnummer::
PRSI90-235
Beschreibung:
IL-1RI is the receptor for interleukin-1alpha (IL-1A), beta (IL-1B) and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappaB. Signaling involves formation of a ternary complex containing IL1RAP, leading the activation of TOLLIP, MYD88 and IRAK1 or IRAK2.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-4005R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-CY7
Lokale Artikelnummer::
BOSSBS-4005R-CY7
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10030R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10030R-FITC
Lokale Artikelnummer::
BOSSBS-10030R-FITC
Beschreibung:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Acetonitril ≥99,9% für die HPLC, für Gradient-Grad fernes UV
Artikel-Nr:
(97574-100ML)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
97574-100ML
Lokale Artikelnummer::
HONC97574-100ML
Beschreibung:
Natriumformiat-Lösung 10 mM NaOH in 2-Propanol/ Wasser (2:3) (1:1) (+0.2% HCOOH) für die LC-MS, Fluka™
VE:
1 * 100 mL
Artikel-Nr:
(ICNA0855526)
Lieferant:
MP Biomedicals
Hersteller-Artikelnummer::
0855526
Lokale Artikelnummer::
ICNA0855526
Beschreibung:
This product is fluorescein-5-isothiocyanate (FITC "Isomer I")-conjugated goat affinity purified F(ab')2 fragments to mouse immunoglobulins (IgG,IgA,IgM) and buffer salts.The total protein is measured by absorbance (A)280 nm); F/P ratio is calculated using absorbance at 491.5nm. Antibody titer of the affinity purified F(ab')2fragments is standardized with an in-house control by immunoelectrophoresis. The affinity purified F(ab')2 fragment is tested for purity at 10 mg/mL using immunoelectrophoresis. The product is goat F(ab')2; no trace of albumin, whole molecule IgG or Fc is detected. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strongly acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.
VE:
1 * 2 mg
Artikel-Nr:
(710-0746)
Lieferant:
DOEHLER GROUP
Hersteller-Artikelnummer::
204723646
Lokale Artikelnummer::
DOEH204723646
Beschreibung:
These nutrient media can be used for simple, quick and efficient detection of microbiological contamination of all beverage types, allowing microorganisms to be identified long before sub-standard finished goods leave the factory. Virtually all detection media are provided ready-to use. Ideal for all types of samples in the non-alcoholic beverage and brewing industries, for water analyses in breweries and other beverage plants, for weak-spot analysis, for checking aseptic filling lines, to detect Alicyclobacilli (according to Standard IFU Method No. 12), or to assess the risk potential (guaiacol formation) from Alicyclobacilli (according to Standard IFU Method No. 12). Bottles have a content of 250 ml.
VE:
1 * 20 ST
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Azithromycin
Artikel-Nr:
(PRSI50-241)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-241
Lokale Artikelnummer::
PRSI50-241
Beschreibung:
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).
VE:
1 * 100 µl
Lieferant:
Palintest
Beschreibung:
Photometer tablet reagents are ideal format for the testing of drinking water, natural water, wastewater and other process applications.
Artikel-Nr:
(PRSI90-076)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-076
Lokale Artikelnummer::
PRSI90-076
Beschreibung:
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
VE:
1 * 10 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Growth regulated protein alpha (GRO-α), also known as CXCL1, is a chemokine that has mitogenic properties and is a neutrophil chemoattractant. GRO-α is secreted by macrophages, epithelial cells, neutrophils, and melanomas. GRO-α signals through the CXCR2 chemokine receptor and is important during spinal cord formation, inflammation, angiogenesis, tumorigenesis, and wound healing.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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