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[cis-3-Methoxycyclobutyl]methanamine+hydrochloride
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[cis-3-Methoxycyclobutyl]methanamine+hydrochloride
Artikel-Nr:
(BOSSBS-5150R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5150R-A555
Lokale Artikelnummer::
BOSSBS-5150R-A555
Beschreibung:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5150R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5150R-A488
Lokale Artikelnummer::
BOSSBS-5150R-A488
Beschreibung:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
VE:
1 * 100 µl
Lieferant:
G-Biosciences
Beschreibung:
Tris is an abbreviation of the organic compound known as tris(hydroxymethyl)aminomethane, with the formula (HOCH2)3CNH2. Tris is extensively used in as a major component in buffer solutions.
Lieferant:
LGC Standards PROMOCHEM
Beschreibung:
This solution is intended for use as a certified reference material (CRM) and calibration standard, for ion chromatography (IC) and techniques using other modes of aqueous ion detection.
Artikel-Nr:
(STRE21-1000-500MG)
Lieferant:
Strem Chemicals, Inc.
Hersteller-Artikelnummer::
21-1000-500MG
Lokale Artikelnummer::
STRE21-1000-500MG
Beschreibung:
Metal Beta-diketonates, Metal TMHD, Volatile Precursors for CVD
VE:
1 * 500 mg
 This is a MarketSource item. Additional charges may apply
Lieferant:
Merck
Beschreibung:
tri-Natriumcitrat, wasserfrei, EMPROVE® ESSENTIAL USP, FCC, E331, SAFC®
Artikel-Nr:
(COBBQA-4827-25G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
QA-4827-25G
Lokale Artikelnummer::
COBBQA-4827-25G
Beschreibung:
Brom-tris-pyrrolidinophosphoniumhexafluorophosphat
VE:
1 * 25 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(HYPETS-38832)
Lieferant:
Thermo Fisher Scientific
Hersteller-Artikelnummer::
TS-38832
Lokale Artikelnummer::
HYPETS-38832
Beschreibung:
N,O-Bis(trimethylsilyl)trifluoracetamid mit 1% Chlortrimethylsilan
VE:
1 * 10 g
Lieferant:
Sigma-Aldrich
Beschreibung:
tri-Kaliumcitrat Monohydrat, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-10460R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10460R-A647
Lokale Artikelnummer::
BOSSBS-10460R-A647
Beschreibung:
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10460R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10460R-HRP
Lokale Artikelnummer::
BOSSBS-10460R-HRP
Beschreibung:
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10460R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10460R-A350
Lokale Artikelnummer::
BOSSBS-10460R-A350
Beschreibung:
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13476R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13476R-A647
Lokale Artikelnummer::
BOSSBS-13476R-A647
Beschreibung:
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11663R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11663R-FITC
Lokale Artikelnummer::
BOSSBS-11663R-FITC
Beschreibung:
Phosphatidylethanolamine (PtdEtn) is a major membrane phospholipid which serves to play a primary role in cell membrane structure and is also involved in cell division, cell signaling, activation, phagocytosis and autophagy. PCYT2 (Phosphorylethanolamine transferase), also known as Ethanolamine-phosphate cytidylyltransferase, is a 389 amino acid protein that catalyzes the formation of CDP-ethanolamine from ethanolamine. This product combined with diacylglycerol form phosphatidylethanolamine via the de novo Kennedy pathway. PCYT2 is expressed at highest levels in heart, liver and skeletal muscle. Elevated levels of MyoD, reduced content of Sp1 and a changed ratio of Sp1 to Sp3 all together stimulate upregulation of PCTY2 transcription during C2C12 muscle cell differentiation. Disruption of the PCYT2 gene in mice leads to death after embryo implantation, establishing the necessity of PCYT2 for murine development.
VE:
1 * 100 µl
Artikel-Nr:
(91116.001)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC91116.001
Beschreibung:
A standard mixture, typically used for food testing, containing the following components: 100 ug/ml each of Acetochlor [CAS:34256-82-1] ; Alachlor [CAS:15972-60-8] ; Allidochlor [CAS:93-71-0] ; Clomazone [CAS:81777-89-1] ; Cycloate [CAS:1134-23-2] ; Diallate [CAS:2303-16-4] ; Dimethachlor [CAS:50563-36-5] ; Diphenamid [CAS:957-51-7] ; Fenpropathrin [CAS:39515-41-8] ; Fluquinconazole [CAS:136426-54-5] ; Flutolanil [CAS:66332-96-5] ; Linuron [CAS:330-55-2] ; Metazachlor [CAS:67129-08-2] ; Methoxychlor (DMTD) [CAS:72-43-5] ; Metolachlor [CAS:51218-45-2] ; N-(2,4-Dimethylphenyl)formamide [CAS:60397-77-5] ; Norflurazon [CAS:27314-13-2] ; Oxadiazon [CAS:19666-30-9] ; Pebulate [CAS:1114-71-2] ; Pretilachlor [CAS:51218-49-6] ; Prochloraz [CAS:67747-09-5] ; Propachlor [CAS:1918-16-7] ; Propanil [CAS:709-98-8] ; Propisochlor [CAS:86763-47-5] ; Propyzamide [CAS:23950-58-5] ; Pyridaben [CAS:96489-71-3] ; Tebufenpyrad [CAS:119168-77-3] ; Tri-allate [CAS:2303-17-5] in Toluene
VE:
1 * 1 mL
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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