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(1R,5S)-8-Azabicyclo[3.2.1]octan-3-one
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(1R,5S)-8-Azabicyclo[3.2.1]octan-3-one
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Artikel-Nr:
(ABCAAB224118-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB224118-100
Lokale Artikelnummer::
ABCAAB224118-100
Beschreibung:
Anti-PIKE Rabbit Polyclonal Antibody
VE:
1 * 100 µl
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-11763R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11763R-A647
Lokale Artikelnummer::
BOSSBS-11763R-A647
Beschreibung:
Sulfation is an essential conjugation reaction that increases the water solubility of many compounds, thereby influencing their renal excretion and also resulting in the formation of active metabolites. SULT4A1 (sulfotransferase family 4A, member 1), whose alternative names include brain sulfotransferase-like protein, nervous system sulfotransferase, NST, SULTX3, hBR-STL-1, BRSTL1, BR-STL-1, MGC40032 and DJ388M5.3, is a 284 amino acid protein showing cytoplasmic localization. As a member of the sulfotransferase 1 family, SULT4A1 plays a role in elimination of xenobiotics, activation of procarcinogens and regulation of hormones. SULT4A1 is highly expressed in cerebral cortex and frontal lobe, with lower expression in cerebellum, temporal and occipital lobes. Two SULT4A1 isoforms exist to alternative splicing events. The gene encoding SULT4A1 maps to human chromosome 22q13.2, a region which has been implicated in predisposition to schizophrenia.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
Artikel-Nr:
(PRSI30-071)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-071
Lokale Artikelnummer::
PRSI30-071
Beschreibung:
CHST1 catalyzes the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. It has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. It may function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. It participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.
VE:
1 * 100 µG
Artikel-Nr:
(USBIC1035-22H-BIOT)
Lieferant:
US Biological
Hersteller-Artikelnummer::
C1035-22H-BIOT
Lokale Artikelnummer::
USBIC1035-22H-BIOT
Beschreibung:
Anti-CAMK1G Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-3815R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3815R-CY5.5
Lokale Artikelnummer::
BOSSBS-3815R-CY5.5
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3815R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3815R-CY5
Lokale Artikelnummer::
BOSSBS-3815R-CY5
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5625R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5625R-CY7
Lokale Artikelnummer::
BOSSBS-5625R-CY7
Beschreibung:
The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor),Beta-synuclein (also designated PNP 14 for neuroprotein 14)and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer’s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson’s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0025M-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0025M-CY3
Lokale Artikelnummer::
BOSSBS-0025M-CY3
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Three alternative splice variants of PSEN1 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(ROCK618-109-012)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
618-109-012
Lokale Artikelnummer::
ROCK618-109-012
Beschreibung:
Secondary Goat Anti-IgG (gamma chain) Reacts with Ferret
VE:
1 * 1 mg
Lieferant:
VWR Seradigm
Beschreibung:
VWR® Seradigm FBS in Spitzenqualität bietet höchste Produktqualität und Virensicherheit, da es zusätzlichen BVD-Virustests mithilfe der qPCR-Technologie unterzogen wird. VWR® Seradigm FBS in Premiumqualität wird vielfach von Zellenzüchtern verwendet, die hochwertiges, leistungsstarkes FBS für verschiedene Anwendungen benötigen.
Artikel-Nr:
(ABGEAP7253B)
Lieferant:
Abgent
Hersteller-Artikelnummer::
AP7253B
Lokale Artikelnummer::
ABGEAP7253B
Beschreibung:
Anti-CAMK1G Rabbit Polyclonal Antibody
VE:
1 * 400 µl
Artikel-Nr:
(BOSSBS-1322R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1322R-CY3
Lokale Artikelnummer::
BOSSBS-1322R-CY3
Beschreibung:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3968R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3968R-A750
Lokale Artikelnummer::
BOSSBS-3968R-A750
Beschreibung:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4250R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4250R-A350
Lokale Artikelnummer::
BOSSBS-4250R-A350
Beschreibung:
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4250R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4250R-A750
Lokale Artikelnummer::
BOSSBS-4250R-A750
Beschreibung:
The three dimensional structure of many extracellular proteins is stabilised by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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