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cis-2-Benzylamino-cyclohexanol+hydrochloride
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cis-2-Benzylamino-cyclohexanol+hydrochloride
Artikel-Nr:
(BOSSBS-10471R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10471R-A750
Lokale Artikelnummer::
BOSSBS-10471R-A750
Beschreibung:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13338R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13338R-A647
Lokale Artikelnummer::
BOSSBS-13338R-A647
Beschreibung:
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0598R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0598R-A350
Lokale Artikelnummer::
BOSSBS-0598R-A350
Beschreibung:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2378R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2378R-A647
Lokale Artikelnummer::
BOSSBS-2378R-A647
Beschreibung:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5357R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5357R-A680
Lokale Artikelnummer::
BOSSBS-5357R-A680
Beschreibung:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5094R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5094R-A750
Lokale Artikelnummer::
BOSSBS-5094R-A750
Beschreibung:
UROD is the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. Porphyria cutanea tarda is an autosomal dominant disorder characterised by light-sensitive dermatitis and associated with the excretion of large amounts of uroporphyrin in urine. Hepatoerythropoetic porphyria is a form of porphyria cutanae tarda that may also be a manifestation of benign or malignant hepatic tumors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-18169R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-18169R-A750
Lokale Artikelnummer::
BOSSBS-18169R-A750
Beschreibung:
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2931R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2931R-CY7
Lokale Artikelnummer::
BOSSBS-2931R-CY7
Beschreibung:
Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors, such as lymph node involvement.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5204R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5204R-A647
Lokale Artikelnummer::
BOSSBS-5204R-A647
Beschreibung:
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0806R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0806R-CY3
Lokale Artikelnummer::
BOSSBS-0806R-CY3
Beschreibung:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6516R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6516R-A680
Lokale Artikelnummer::
BOSSBS-6516R-A680
Beschreibung:
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3521R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3521R-CY5.5
Lokale Artikelnummer::
BOSSBS-3521R-CY5.5
Beschreibung:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4989R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4989R-CY5.5
Lokale Artikelnummer::
BOSSBS-4989R-CY5.5
Beschreibung:
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5660R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5660R-CY7
Lokale Artikelnummer::
BOSSBS-5660R-CY7
Beschreibung:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5661R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5661R
Lokale Artikelnummer::
BOSSBS-5661R
Beschreibung:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5357R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5357R
Lokale Artikelnummer::
BOSSBS-5357R
Beschreibung:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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