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Trisodium+naphthalene-1,3,5-trisulphonate
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Trisodium+naphthalene-1,3,5-trisulphonate
Artikel-Nr:
(BOSSBS-0232R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0232R-A555
Lokale Artikelnummer::
BOSSBS-0232R-A555
Beschreibung:
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11844R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11844R-HRP
Lokale Artikelnummer::
BOSSBS-11844R-HRP
Beschreibung:
GEFT is a 580 amino acid cytoplasmic protein that is highly expressed in excitable tissues such as brain, heart and muscle, and weakly expressed in small intestine, colon, liver, placenta and lung. GEFT may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. GEFT works as a guanine nucleotide exchange factor for the Rho family of small GTPases and links specifically to G alpha q/11-coupled receptors in Rho A activation. GEFT is an important regulator of processes involved in axon and dendrite formation. Involved in skeletal myogenesis, GEFT seems to be an exchange factor primarily for Rac 1 in neurons. Existing as two alternatively spliced variants, GEFT contains a DH (DBL-homology) domain and a PH domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5199R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5199R-A488
Lokale Artikelnummer::
BOSSBS-5199R-A488
Beschreibung:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4010R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4010R-A555
Lokale Artikelnummer::
BOSSBS-4010R-A555
Beschreibung:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12486R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12486R-CY7
Lokale Artikelnummer::
BOSSBS-12486R-CY7
Beschreibung:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12486R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12486R-CY3
Lokale Artikelnummer::
BOSSBS-12486R-CY3
Beschreibung:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7832R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7832R-CY5
Lokale Artikelnummer::
BOSSBS-7832R-CY5
Beschreibung:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1199R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1199R
Lokale Artikelnummer::
BOSSBS-1199R
Beschreibung:
This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1199R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1199R-CY3
Lokale Artikelnummer::
BOSSBS-1199R-CY3
Beschreibung:
This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2162R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2162R-CY3
Lokale Artikelnummer::
BOSSBS-2162R-CY3
Beschreibung:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5786R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5786R-CY5.5
Lokale Artikelnummer::
BOSSBS-5786R-CY5.5
Beschreibung:
Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2162R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2162R-CY5
Lokale Artikelnummer::
BOSSBS-2162R-CY5
Beschreibung:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4212R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4212R-CY5.5
Lokale Artikelnummer::
BOSSBS-4212R-CY5.5
Beschreibung:
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10466R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10466R-A750
Lokale Artikelnummer::
BOSSBS-10466R-A750
Beschreibung:
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
VE:
1 * 100 µl
Artikel-Nr:
(ABCAAB283387-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB283387-100
Lokale Artikelnummer::
ABCAAB283387-100
Beschreibung:
It is simple and can be used to identify and characterize CA inhibitors in a high-throughput format.
VE:
1 * 100 Tests
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-11552R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11552R-A750
Lokale Artikelnummer::
BOSSBS-11552R-A750
Beschreibung:
The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson's disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been associated with cerebellar hypoplasia.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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