3-(3-Methoxyphenyl)-1-propene
Artikel-Nr:
(BOSSBS-7758R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7758R-HRP
Lokale Artikelnummer::
BOSSBS-7758R-HRP
Beschreibung:
Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5582R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5582R-A750
Lokale Artikelnummer::
BOSSBS-5582R-A750
Beschreibung:
Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1306R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1306R-CY7
Lokale Artikelnummer::
BOSSBS-1306R-CY7
Beschreibung:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13041R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13041R-CY5
Lokale Artikelnummer::
BOSSBS-13041R-CY5
Beschreibung:
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11490R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11490R-A750
Lokale Artikelnummer::
BOSSBS-11490R-A750
Beschreibung:
A mutation of the DYT1 gene, which codes for TorsinA, has been identified as the cause of one form of autosomal dominantly inherited dystonia. Early-onset torsion dystonia is a movement disorder, characterised by twisting muscle contractures, that begins in childhood. Symptoms are believed to result from altered neuronal communication in the basal ganglia. TorsinA comprises 332 amino acids. TorsinA is widely expressed throughout the mouse central nervous system and is detected in the majority of neurons in nearly all regions. The proteins display cytoplasmic distribution, although in some types of neurons localisation is perinuclear. TorsinA often performs chaperone-like functions that assist in the assembly, operation, or dis-assembly of protein complexes. The gene which encodes TorsinA has high homology to three additional mammalian genes and a nematode gene and distal similarity to the family of heat-shock proteins and the Clp protease family. The gene which encodes TorsinA maps to human chromosome 9q34.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5695R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5695R-CY5.5
Lokale Artikelnummer::
BOSSBS-5695R-CY5.5
Beschreibung:
Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12488R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12488R-HRP
Lokale Artikelnummer::
BOSSBS-12488R-HRP
Beschreibung:
This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11825R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11825R-A488
Lokale Artikelnummer::
BOSSBS-11825R-A488
Beschreibung:
DOCK 7 is a 2,140 amino acid protein that localizes to developing axons and contains one DHR-1 domain and one DHR-2 domain. Expressed in a variety of tissues, DOCK 7 functions as a guanine nucleotide exchange factor (GEF) that specifically activates Rac 1 and Rac 3 by catalyzing the exchange of bound GDP for free GTP. Multiple isoforms of DOCK 7 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3989R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3989R-A488
Lokale Artikelnummer::
BOSSBS-3989R-A488
Beschreibung:
Glycogen synthase catalyzes the rate-limiting step in glycogen synthesis. Its activity is regulated by a complex phosphorylation-dephosphorylation mechanism and by allosteric stimulators and inhibitors. Two isozymes of synthase, a skeletal muscle type (Glycogen synthase 1 - GYS1) and a liver type (Glycogen synthase 2 - GYS2), have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13614R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13614R-HRP
Lokale Artikelnummer::
BOSSBS-13614R-HRP
Beschreibung:
AMAP-1 (AMY-1-binding protein 1), also known as AMAM-1 or MYCBPAP (MYCBP associated protein), is a 947 amino acid protein that is expressed specifically in testis and is involved in spermatogenesis and synaptic processes. AMAP-1 colocalizes with MYCBP (AMY-1) in cytoplasm and also localizes to membrane. The gene encoding AMAP-1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1827R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1827R-HRP
Lokale Artikelnummer::
BOSSBS-1827R-HRP
Beschreibung:
Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production.Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1961R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1961R-CY7
Lokale Artikelnummer::
BOSSBS-1961R-CY7
Beschreibung:
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4965R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4965R
Lokale Artikelnummer::
BOSSBS-4965R
Beschreibung:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3174R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3174R-CY3
Lokale Artikelnummer::
BOSSBS-3174R-CY3
Beschreibung:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0267R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R-A647
Lokale Artikelnummer::
BOSSBS-0267R-A647
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4219R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4219R
Lokale Artikelnummer::
BOSSBS-4219R
Beschreibung:
Anti-TBL1X Rabbit Polyclonal Antibody
VE:
1 * 100 µl
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