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Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-Chlor-2-fluor-5-(methoxycarbonyl)phenylboronsäurepinakolester
Lieferant:
Alfa Aesar
Beschreibung:
1-Methylcyclohexen 96%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-(2-Methylallyloxy)benzaldehyde 95%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-(3-Methylbutoxy)benzaldehyde 98%
Artikel-Nr:
(BOSSBS-4098R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4098R
Lokale Artikelnummer::
BOSSBS-4098R
Beschreibung:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6144R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6144R-A750
Lokale Artikelnummer::
BOSSBS-6144R-A750
Beschreibung:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilising properties and the half-life of their target mRNAs.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD631078-5MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD631078-5MG
Lokale Artikelnummer::
BLDPBD631078-5MG
Beschreibung:
Droxinostat 98%
VE:
1 * 5 mg
Artikel-Nr:
(BOSSBS-9486R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9486R-A350
Lokale Artikelnummer::
BOSSBS-9486R-A350
Beschreibung:
A crucial regulator of chromatin dynamics and DNA transcription is the covalent modification and methylation of histones. Generally, methylation of certain lysine residues on Histone H3 and Histone H4 can be associated with transcriptionally active or inactive chromatin. This regulation has profound effects on the expression of genes and is part of an epigenetic memory network that determines cell fate. JMJD7 (Jumonji domain-containing protein 7) is a member of a family of JMJC domain-containing histone demethylases that are directly involved in removing methyl residues from distinct and unique lysine residues. These actions are implicated in gene expression and the regulation of cell senescence. JMJC domain-containing histone demethylases are also likely involved in development via their ability to regulate gene expression. JMJD7 contains one JMJC domain and was originally thought to be an alternatively spliced isoform of PLA2G4B.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
N-Benzhydryl-N-methylamine 98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-Piperidin-1-ylmethylbenzylamine 97%
Lieferant:
Thermo Scientific
Beschreibung:
(S)-N-Boc-α-ethylalanine 98%, 98% ee
Lieferant:
Alfa Aesar
Beschreibung:
3-Methylanisol ≥99%
Artikel-Nr:
(BOSSBS-11866R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11866R-A647
Lokale Artikelnummer::
BOSSBS-11866R-A647
Beschreibung:
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR917141-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR917141-5G
Lokale Artikelnummer::
APOSOR917141-5G
Beschreibung:
2-(4-Chlorphenyl)-2-methyl-1-propanol 98%
VE:
1 * 5 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Brom-5-methylpyridin
Lieferant:
Thermo Scientific
Beschreibung:
Propylencarbonat, wasserfrei 99.5%, AcroSeal™
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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