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3-(Trifluoromethyl)quinoline
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3-(Trifluoromethyl)quinoline
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Artikel-Nr:
(BOSSBS-6634R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-A680
Lokale Artikelnummer::
BOSSBS-6634R-A680
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(1.07537.0100)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.07537.0100
Lokale Artikelnummer::
MERC1.07537.0100
Beschreibung:
Siliciumdioxid, glasartig, Granulat, Patinal® 1-4 mm
VE:
1 * 100 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
(R)-4,5,6-Tetrahydro-3H-pyrrolo[1,2-c]oxathiazole 1,1-dioxide 95%
Artikel-Nr:
(APOSOR318128-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR318128-1G
Lokale Artikelnummer::
APOSOR318128-1G
Beschreibung:
2-Methyl-2,3-dihydro-1,2-benzisothiazol-3-ol 1,1-dioxide 95+%
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD305212-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD305212-1G
Lokale Artikelnummer::
BLDPBD305212-1G
Beschreibung:
2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide 97+%
VE:
1 * 1 g
Artikel-Nr:
(87951.180)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87951.180
Beschreibung:
Formaldehyd 0,4% in Schwefelsäure 95% Reag. Ph. Eur. 1086805
VE:
1 * 100 mL
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-Oxa-2-thia-1-azaspiro[4.4]nonane 2,2-dioxide, N-BOC protected 95%
Artikel-Nr:
(BOSSBS-6634R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-A488
Lokale Artikelnummer::
BOSSBS-6634R-A488
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-CY7
Lokale Artikelnummer::
BOSSBS-6634R-CY7
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Lieferant:
VWR Chemicals
Beschreibung:
Polysulphide CRMs are suitable for calibration, verification, or for use in quality control procedures used for analysing sulphur content in petroleum products.
Lieferant:
Merck
Beschreibung:
Phenolrot ACS
Artikel-Nr:
(45596.K2)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
45596.K2
Lokale Artikelnummer::
ALFA45596.K2
Beschreibung:
Schwefelsäure ≥72% (w/w)
VE:
1 * 1 L
Artikel-Nr:
(42555.K2)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
42555.K2
Lokale Artikelnummer::
ALFA42555.K2
Beschreibung:
Schwefelsäure ≥75% (v/v)
VE:
1 * 1 L
Lieferant:
VWR Chemicals
Beschreibung:
Gesättigte Chrom(VI)Oxid-Lösung in H<sub>2</sub>SO<sub>4</sub> 95 %.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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