4\\\'-Acetylbiphenyl-3-carbons\u00E4ure
Lieferant:
Biotium
Beschreibung:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Artikel-Nr:
(BOSSBS-11427R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11427R-A647
Lokale Artikelnummer::
BOSSBS-11427R-A647
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
VE:
1 * 100 µl
Artikel-Nr:
(LENZ07105300)
Lieferant:
Lenz Laborglas GmbH & CO.KG
Hersteller-Artikelnummer::
07105300
Lokale Artikelnummer::
LENZ07105300
Beschreibung:
Diese Schraubverschlüsse bestehen aus Polypropylen.
VE:
1 * 10 ST
Artikel-Nr:
(BLEG204208)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
204208
Lokale Artikelnummer::
BLEG204208
Beschreibung:
Anti-CD48 Mouse Monoclonal Antibody [clone: OX-45]
VE:
1 * 100 µG
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Artikel-Nr:
(NICK695)
Lieferant:
NICKEL ELECTRO
Hersteller-Artikelnummer::
695
Lokale Artikelnummer::
NICK695
Beschreibung:
Stainless steel.
VE:
1 * 1 ST
Artikel-Nr:
(BLEG409502)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
409502
Lokale Artikelnummer::
BLEG409502
Beschreibung:
Anti-Ig light chain κ Rat Monoclonal Antibody [clone: RMK-45]
VE:
1 * 500 µG
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Artikel-Nr:
(23347.105)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC23347.105
Beschreibung:
2,6-Dichlorphenol-indophenol Natriumsalz Hydrat ACS analytisches Reagens
VE:
1 * 5 g
Artikel-Nr:
(MOLE25454876-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
25454876-25G
Lokale Artikelnummer::
MOLE25454876-25G
Beschreibung:
Chromotropsäure Dinatriumsalz Dihydrat
VE:
1 * 25 g
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Artikel-Nr:
(PROOCIL-PCB-200)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-200
Lokale Artikelnummer::
PROOCIL-PCB-200
Beschreibung:
Organic Standard, 2,2',3,3',4,5',6,6'-Octachlorbiphenyl (PCB Nr. 200) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
Lieferant:
Thermo Scientific
Beschreibung:
Chromotropsäure Dinatriumsalz Dihydrat ACS
Artikel-Nr:
(BRND130322)
Lieferant:
Brand
Hersteller-Artikelnummer::
130322
Lokale Artikelnummer::
BRND130322
Beschreibung:
Schraubverschlüsse, Für: Wide neck bottles, Farbe: Blau, PP, Gewinde: GL 45, Für Flaschen: 250 ml
VE:
1 * 100 ST
Artikel-Nr:
(BOSSBS-11698R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11698R-A647
Lokale Artikelnummer::
BOSSBS-11698R-A647
Beschreibung:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13247R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13247R-FITC
Lokale Artikelnummer::
BOSSBS-13247R-FITC
Beschreibung:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein Alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their Alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G Alpha subunits have been identified; these include G Alpha s, G Alpha i, G Alpha q and G Alpha 12/13. The two members of the fourth class of G Alpha subunit proteins, G Alpha 12 and G Alpha 13, are insensitive to ADP-ribosylation by pertussis toxin, share 67% identity with each other and less than 45% identity with other G Alpha subunits and are widely expressed in a broad range of tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6987R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6987R-FITC
Lokale Artikelnummer::
BOSSBS-6987R-FITC
Beschreibung:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6987R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6987R-A555
Lokale Artikelnummer::
BOSSBS-6987R-A555
Beschreibung:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6987R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6987R-CY5
Lokale Artikelnummer::
BOSSBS-6987R-CY5
Beschreibung:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Preis auf Anfrage
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