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2-Aminoadamantane-2-carboxylic+acid
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2-Aminoadamantane-2-carboxylic+acid
Artikel-Nr:
(BOSSBS-1135R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-FITC
Lokale Artikelnummer::
BOSSBS-1135R-FITC
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY7
Lokale Artikelnummer::
BOSSBS-1135R-CY7
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(87805.180)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87805.180
Beschreibung:
Kongorot 0,1% in Ethanol 15% (v/v) Reag. Ph. Eur. 1022001
VE:
1 * 100 mL
Lieferant:
Restek
Beschreibung:
Use these liners for increased sensitivity. They are manufactured from borosilicate glass or metal.
Lieferant:
Thermo Scientific
Beschreibung:
4-Chlor-N-(4-(3,4,5-tribrom-1H-pyrazol-1-yl)phenyl)benzolsulfonamid
Artikel-Nr:
(COBBBB-6445-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
BB-6445-1G
Lokale Artikelnummer::
COBBBB-6445-1G
Beschreibung:
4-Propylcyclohexen-1-ylboronsäure
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Thermo Scientific
Beschreibung:
2,5-Dichlor-4-nitroanilin
Artikel-Nr:
(FITZ20-BR20)
Lieferant:
Fitzgerald Industries
Hersteller-Artikelnummer::
20-BR20
Lokale Artikelnummer::
FITZ20-BR20
Beschreibung:
D(+)-Biotin
VE:
1 * 1 mL
Lieferant:
COMBI-BLOCKS
Beschreibung:
Kalium(2-(benzyloxy)phenyl)trifluoroborat
Lieferant:
Sigma-Aldrich
Beschreibung:
5-Bromuridin, Sigma-Aldrich®
Lieferant:
Alfa Aesar
Beschreibung:
L(+)-Ascorbinsäure ≥99%
Lieferant:
Bernd Kraft
Beschreibung:
Calciumcarbonat analytisches Reagens, gefällt
Artikel-Nr:
(PRSI30-067)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-067
Lokale Artikelnummer::
PRSI30-067
Beschreibung:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein.The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.
VE:
1 * 50 µG
Lieferant:
Alfa Aesar
Beschreibung:
Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.
Lieferant:
Sigma-Aldrich
Beschreibung:
Bortrichlorid 1 mol/l in p-Xylol, Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
1-Ethyl-3-methylimidazoliumiodid, Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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