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6-Fluorobenzo[d]isoxazol-3(2H)-one
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6-Fluorobenzo[d]isoxazol-3(2H)-one
Artikel-Nr:
(BOSSBS-9576R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9576R-A680
Lokale Artikelnummer::
BOSSBS-9576R-A680
Beschreibung:
Copine 6 is a 557 amino acid member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Arabidopsis thaliana mutants lacking copine proteins exhibit reduced cell number and smaller cell size, effects which may be due to a defect in vesicle fusion or transport. Copine 6 contains two N-terminal C2 domains and one C-terminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine 6 functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Copine 6 may also play a role in synaptic plasticity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9103R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9103R-A488
Lokale Artikelnummer::
BOSSBS-9103R-A488
Beschreibung:
Mono-ADP-ribosylation is one of the posttranslational protein modifications regulating cellular metabolism (e.g. nitrogen fixation) in prokaryotes. Mono-ADP-ribosylation is a process in which the ADP-ribose moiety of nicotinamide adenine dinucleotide is transferred to an acceptor amino acid. Five mammalian ADP-ribosyltransferases (ART1-ART5) have been cloned, and expression is restricted to tissues such as cardiac and skeletal muscle, leukocytes, brain and testis. ART3 (ADP-ribosyltransferase 3), also known as Ecto-ADP-ribosyltransferase 3, is a testis specific membrane protein that does not appear to have ADP-ribosyltransferase activity. It lacks the R-S-EXE active site motif and is therefore unable to catalyze the reaction. ART3 is predominantly found in spermatocytes and may play a role in spermatogenesis.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Artikel-Nr:
(BOSSBS-13030R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13030R-A350
Lokale Artikelnummer::
BOSSBS-13030R-A350
Beschreibung:
ZBED1 is a 694 amino acid protein that localizes specifically to granular structures within the nucleus. Expressed ubiquitously at low levels and present at higher levels in heart, placenta, spleen and skeletal muscle, ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoding genes, thereby playing a role in the cell cycle and in cell proliferation events. ZBED1 contains one BED-type zinc finger and binds specifically to 5'-TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors. Additionally, ZBED1 binds strongly to the promotor region of Histone H1 (a protein required for the condensation of nucleosomes into higher order structures), subsequently activating H1 transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13222R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13222R-A647
Lokale Artikelnummer::
BOSSBS-13222R-A647
Beschreibung:
FSD2 is a 749 amino acid protein containing one B30.2/SPRY domain and two fibronectin type-III domains. The gene encoding FSD2 maps to human chromosome 15q25.2. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and consists of about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are also associated with chromosome 15.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8237R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8237R-CY5.5
Lokale Artikelnummer::
BOSSBS-8237R-CY5.5
Beschreibung:
FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD5 (FERM domain-containing protein 5) is a 570 amino acid single-pass membrane protein that contains one FERM domain and exists as two alternatively spliced isoforms. The gene encoding FRMD5 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8226R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8226R-A488
Lokale Artikelnummer::
BOSSBS-8226R-A488
Beschreibung:
FAM161B is a 647 amino acid protein that belongs to the FAM161 family. The gene that encodes FAM161B consists of approximately 16,413 bases and maps to human chromosome 14q24.3. Housing over 700 genes, chromosome 14 comprises nearly 3.5% of the human genome. Chromosome 14 encodes the Presenilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer’s disease. The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. An inversion of the long arm of chromosome 14 is thought to be involved in T-cell chronic lymphocytic leukemia (CLL), a cancer that affects T lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2544R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2544R-CY5
Lokale Artikelnummer::
BOSSBS-2544R-CY5
Beschreibung:
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11895R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11895R-CY7
Lokale Artikelnummer::
BOSSBS-11895R-CY7
Beschreibung:
NELL2 is a secreted glycoprotein with one N-terminal TSP-like domain, five VWFC (von Willebrand factor C) domains and six EGF-like repeats that participate in calcium binding. NELL2 exists as a homotrimer associated with the endoplasmic reticulum (ER) and is specifically expressed in neurons playing a role in calcium-dependent intracellular events. NELL2 may act as a trophic factor in addition to its role as a signaling molecule implicated in the regulation of cell growth and differentiation. Due to alternative splicing, an additional NELL2 isoform exists that is identical to full length NELL2 except that it lacks the signal peptide that directs secretion. The additional isoform is therefore retained in the cytosol and functions as a non-secreted cytoplasmic protein that interacts with PKC bI.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12411R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12411R-CY5
Lokale Artikelnummer::
BOSSBS-12411R-CY5
Beschreibung:
Prickle1 is an 831 amino acid protein that contains one PET domain and three LIM zinc-binding domains and localizes to the cytoplasm, as well as to the nuclear membrane. Expressed at higher levels in placenta and at lower levels in liver, brain, kidney, lung and pancreas, Prickle1 is thought to function as a nuclear receptor that interacts with NRSF, a silencer protein that binds the DNA sequence element NRSE (neuron-restrictive silencer element). Defects in the gene encoding Prickle1 are associated with autosomal recessive progressive myoclonic epilepsy-1B, which is characterized by quick jerks of the arms, shoulders or legs. The gene encoding Prickle1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4728R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4728R-A750
Lokale Artikelnummer::
BOSSBS-4728R-A750
Beschreibung:
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11365R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11365R-CY5
Lokale Artikelnummer::
BOSSBS-11365R-CY5
Beschreibung:
In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9336R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9336R-A350
Lokale Artikelnummer::
BOSSBS-9336R-A350
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12247R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12247R-CY5
Lokale Artikelnummer::
BOSSBS-12247R-CY5
Beschreibung:
NAC1 is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homooligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1964R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1964R-FITC
Lokale Artikelnummer::
BOSSBS-1964R-FITC
Beschreibung:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1325R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1325R-A680
Lokale Artikelnummer::
BOSSBS-1325R-A680
Beschreibung:
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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