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1,5-Dinitronaphthalene
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1,5-Dinitronaphthalene
Artikel-Nr:
(BOSSBS-12380R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12380R-CY5
Lokale Artikelnummer::
BOSSBS-12380R-CY5
Beschreibung:
Wnt-induced secreted protein (WISP)-1, WISP-2 and WISP-3 are members of the CCN family of growth factors, which include connective tissue growth factor (CTGF) and Cyr61. WISP-1, WISP-2 and WISP-3 share significant sequence similarity, including four conserved cysteine-rich domains, and they are believed to function as dimers in their active forms. WISP-1 expression is observed in various tissues including adult heart, kidney and spleen, while WISP-2 expression predominates in skeletal muscle, colon and ovary. Both WISP-1 and WISP-2 are upregulated in cells transformed with the proto-oncogene Wnt-1, and they are also more highly expressed in human colon tumors, suggesting that these proteins may participate in tumor development. WISP-3 is involved in normal post-natal skeletal growth, and it is also implicated in the development of the autosomal recessive skeletal disorder progressive pseudorheumatoid dysplasia, which affects cartilage homeostasis by disrupting the growth of chondrocyte and normal cell columnar organization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9162R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9162R-CY5.5
Lokale Artikelnummer::
BOSSBS-9162R-CY5.5
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM17 (tripartite motif-containing 17), also known as RBCC, terf or RNF16, is a 477 amino acid protein that contains one RING-type zinc finger, one SPRY domain and one B box-type zinc finger. Expressed nearly exclusively in testis, TRIM17 belongs to the TRIM family and, based on its functional domains, may play a role in transcriptional regulation events. The gene encoding TRIM17 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2017R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2017R-CY5.5
Lokale Artikelnummer::
BOSSBS-2017R-CY5.5
Beschreibung:
14-3-3 family protein
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2081R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2081R-CY5.5
Lokale Artikelnummer::
BOSSBS-2081R-CY5.5
Beschreibung:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6991R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6991R-CY7
Lokale Artikelnummer::
BOSSBS-6991R-CY7
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, that are characterized by the presence of a nuclear receptor recognition motif which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6772R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6772R-HRP
Lokale Artikelnummer::
BOSSBS-6772R-HRP
Beschreibung:
The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7799R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7799R-A350
Lokale Artikelnummer::
BOSSBS-7799R-A350
Beschreibung:
The product of the GAJ gene associates with HOP2 to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 and DMC1. Both the MND1 and HOP2 genes are indispensable for meiotic recombination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12302R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12302R-CY3
Lokale Artikelnummer::
BOSSBS-12302R-CY3
Beschreibung:
PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3548R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3548R-HRP
Lokale Artikelnummer::
BOSSBS-3548R-HRP
Beschreibung:
Dystrobrevin beta is a component of the dystrophin-associated protein complex and interacts with dystrophin short form DP71, syntrophins SNTG1 and SNTG2. It localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. 4 isoforms produced by alternative splicing have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5955R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5955R
Lokale Artikelnummer::
BOSSBS-5955R
Beschreibung:
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6919R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6919R-CY5.5
Lokale Artikelnummer::
BOSSBS-6919R-CY5.5
Beschreibung:
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC69 (Coiled-coil domain-containing protein 69) is a 296 amino acid protein that is encoded by a gene which maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6743R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6743R-HRP
Lokale Artikelnummer::
BOSSBS-6743R-HRP
Beschreibung:
TPD54
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6668R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6668R-CY5
Lokale Artikelnummer::
BOSSBS-6668R-CY5
Beschreibung:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7049R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7049R-CY3
Lokale Artikelnummer::
BOSSBS-7049R-CY3
Beschreibung:
May play a role as a mediator of inflammation and angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7934R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7934R-CY5
Lokale Artikelnummer::
BOSSBS-7934R-CY5
Beschreibung:
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11242R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11242R-CY5
Lokale Artikelnummer::
BOSSBS-11242R-CY5
Beschreibung:
Adaptins are heterotetrameric subunits of adaptors, which are complexes involved in the formation of Clathrin-coated pits for vesicle-mediated endocytosis. Clathrin and its associated heterotetrameric protein complexes make up the main protein components of the coat surrounding the cytoplasmic face of coated vesicles. The Adaptin family, comprising a, b, and g classes, is also responsible for the transport of ligand-receptor complexes from plasma membranes and the trans-Golgi network to lysosomes. Two main types of adaptor proteins (APs), AP-1 and AP-2, are found in Clathrin-coated structures located at the Golgi complex and the plasma membrane of mammalian cells, respectively. Adaptor protein complex 2 (AP-2) is composed of two large Adaptins (a1A/AP2A1 and b1/AP2B1), a medium Adaptin (m2/AP-2m1) and a small Adaptin (s2 long/AP2S1). AP-2m1, a 435 amino acid protein, links Clathrin to receptors in coated vesicles.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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