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BDP+International+Inc.
Artikel-Nr:
(PRSI33-317)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-317
Lokale Artikelnummer::
PRSI33-317
Beschreibung:
Recognises a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-319)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-319
Lokale Artikelnummer::
PRSI33-319
Beschreibung:
Recognises a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(BOSSBS-2200R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2200R-CY7
Lokale Artikelnummer::
BOSSBS-2200R-CY7
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2200R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2200R-CY5.5
Lokale Artikelnummer::
BOSSBS-2200R-CY5.5
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2200R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2200R-CY3
Lokale Artikelnummer::
BOSSBS-2200R-CY3
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4892R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4892R-CY5
Lokale Artikelnummer::
BOSSBS-4892R-CY5
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5038R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5038R-CY5
Lokale Artikelnummer::
BOSSBS-5038R-CY5
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6501R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6501R-CY3
Lokale Artikelnummer::
BOSSBS-6501R-CY3
Beschreibung:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
VE:
1 * 100 µl
Artikel-Nr:
(PRSI91-583)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-583
Lokale Artikelnummer::
PRSI91-583
Beschreibung:
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-5039R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5039R-A680
Lokale Artikelnummer::
BOSSBS-5039R-A680
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2200R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2200R-A488
Lokale Artikelnummer::
BOSSBS-2200R-A488
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0705R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0705R-A488
Lokale Artikelnummer::
BOSSBS-0705R-A488
Beschreibung:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4892R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4892R-HRP
Lokale Artikelnummer::
BOSSBS-4892R-HRP
Beschreibung:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI96-509)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-509
Lokale Artikelnummer::
PRSI96-509
Beschreibung:
Low-Density Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-6501R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6501R-CY5.5
Lokale Artikelnummer::
BOSSBS-6501R-CY5.5
Beschreibung:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6501R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6501R-A350
Lokale Artikelnummer::
BOSSBS-6501R-A350
Beschreibung:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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