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H-Tyr(BZL)-OMe·HCl
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H-Tyr(BZL)-OMe·HCl
Lieferant:
Biotium
Beschreibung:
This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Lieferant:
Biotium
Beschreibung:
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Artikel-Nr:
(BOSSBS-6943R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6943R-CY5
Lokale Artikelnummer::
BOSSBS-6943R-CY5
Beschreibung:
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6943R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6943R-CY7
Lokale Artikelnummer::
BOSSBS-6943R-CY7
Beschreibung:
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BNUM0948-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0948-50
Lokale Artikelnummer::
BTIUBNUM0948-50
Beschreibung:
This antibody reacts with keratin 5 (58 kDa) and keratin 8 (52.5 kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas.
VE:
1 * 50 µl
Artikel-Nr:
(L19795.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
L19795.03
Lokale Artikelnummer::
ALFAL19795.03
Beschreibung:
1-Amino-4-oxocyclohexanecarboxylic acid ethylene ketal 98%
VE:
1 * 1 g
Lieferant:
Alfa Aesar
Beschreibung:
Methyl-3-amino-5,6-dichlorpyrazin-2-carboxylat 97%
Lieferant:
Avantor
Beschreibung:
Magnesiumchlorid Hexahydrat 99,0-101,0%, Kristalle USP, FCC, J.T.Baker®
Artikel-Nr:
(EHERC14730000)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
C14730000
Lokale Artikelnummer::
EHERC14730000
Beschreibung:
Maleinsäurehydrazid
VE:
1 * 0,25 g
Artikel-Nr:
(BOSSBS-12237R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12237R-CY5
Lokale Artikelnummer::
BOSSBS-12237R-CY5
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF532 is a 1301 amino acid nuclear protein that contains twelve C2H2-type zinc fingers. The gene encoding ZNF532 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases, representing about 2.5% of total DNA in cells. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10756R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10756R-A680
Lokale Artikelnummer::
BOSSBS-10756R-A680
Beschreibung:
MTP18 (Mitochondrial protein 18 kDa) is a downstream target of the phosphatidylinositol 3-kinase Signalling pathway and is essential for cell viability. It may have a role in maintaining the integrity of the mitochondrial network. Loss of function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10756R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10756R-A750
Lokale Artikelnummer::
BOSSBS-10756R-A750
Beschreibung:
MTP18 (Mitochondrial protein 18 kDa) is a downstream target of the phosphatidylinositol 3-kinase Signalling pathway and is essential for cell viability. It may have a role in maintaining the integrity of the mitochondrial network. Loss of function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.
VE:
1 * 100 µl
Lieferant:
VWR Chemicals
Beschreibung:
Magnesiumchlorid Hexahydrat 98,0-101,0% Ph. Eur., USP, BP
Artikel-Nr:
(BOSSBS-6806R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6806R-CY3
Lokale Artikelnummer::
BOSSBS-6806R-CY3
Beschreibung:
Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6806R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6806R-CY7
Lokale Artikelnummer::
BOSSBS-6806R-CY7
Beschreibung:
Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Appearance: Yellow to grey to brown Solution
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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