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H-Tyr(BZL)-OMe·HCl
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H-Tyr(BZL)-OMe·HCl
Artikel-Nr:
(BOSSBS-1979R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1979R-A488
Lokale Artikelnummer::
BOSSBS-1979R-A488
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11434R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11434R-A750
Lokale Artikelnummer::
BOSSBS-11434R-A750
Beschreibung:
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0819R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0819R-A350
Lokale Artikelnummer::
BOSSBS-0819R-A350
Beschreibung:
Tyrosinase is the key enzyme for melanin,synthesis in mammalian melanocytes and has been considered to be a unique marker for the study of melanocyte differentiation. A cDNA library was constructed from poly(A)+ mRNA from mouse melanocytes and screened using anti- tyrosinase antiserum and oligonucleotide probes corresponding to amino acid sequence of tyrosinase. sequencing of some cDNA clones positive in these screenings gave a nucleotide sequence of 1838 nucleotides including a open reading frame of 1344 nucleotides that was found to correspond exactly to the amino acid sequence of the cyanogen bromide fragments of tyrosinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0819R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0819R-HRP
Lokale Artikelnummer::
BOSSBS-0819R-HRP
Beschreibung:
Tyrosinase is the key enzyme for melanin,synthesis in mammalian melanocytes and has been considered to be a unique marker for the study of melanocyte differentiation. A cDNA library was constructed from poly(A)+ mRNA from mouse melanocytes and screened using anti- tyrosinase antiserum and oligonucleotide probes corresponding to amino acid sequence of tyrosinase. sequencing of some cDNA clones positive in these screenings gave a nucleotide sequence of 1838 nucleotides including a open reading frame of 1344 nucleotides that was found to correspond exactly to the amino acid sequence of the cyanogen bromide fragments of tyrosinase.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD143860-10G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD143860-10G
Lokale Artikelnummer::
BLDPBD143860-10G
Beschreibung:
(S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate 95%
VE:
1 * 10 g
Artikel-Nr:
(BOSSBS-9354R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9354R-CY5.5
Lokale Artikelnummer::
BOSSBS-9354R-CY5.5
Beschreibung:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9354R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9354R-CY3
Lokale Artikelnummer::
BOSSBS-9354R-CY3
Beschreibung:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11434R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11434R-A647
Lokale Artikelnummer::
BOSSBS-11434R-A647
Beschreibung:
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1233R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1233R-FITC
Lokale Artikelnummer::
BOSSBS-1233R-FITC
Beschreibung:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
FMOC-O-tert-butyl-L-tyrosine 98% (durch HPLC)
Artikel-Nr:
(BOSSBS-5218R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5218R-A647
Lokale Artikelnummer::
BOSSBS-5218R-A647
Beschreibung:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Artikel-Nr:
(BOSSBS-11434R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11434R-A680
Lokale Artikelnummer::
BOSSBS-11434R-A680
Beschreibung:
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-20158R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20158R-A750
Lokale Artikelnummer::
BOSSBS-20158R-A750
Beschreibung:
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-20158R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20158R-A680
Lokale Artikelnummer::
BOSSBS-20158R-A680
Beschreibung:
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5218R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5218R-CY5
Lokale Artikelnummer::
BOSSBS-5218R-CY5
Beschreibung:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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