Suche >
IGEPAL\\\\\\\\u00AE+CA-630
Drucken
Sie suchten nach:
26 347 results were found
IGEPAL\\\\\\\\u00AE+CA-630
Artikel-Nr:
(BOSSBS-1599R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1599R
Lokale Artikelnummer::
BOSSBS-1599R
Beschreibung:
Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
VE:
1 * 100 µl
Artikel-Nr:
(PRSIPM-5205)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
PM-5205
Lokale Artikelnummer::
PRSIPM-5205
Beschreibung:
ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-523)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-523
Lokale Artikelnummer::
PRSI92-523
Beschreibung:
Mouse Ca14,also known as Carbonic anhydrase 14,is a member of large family of zinc metalloenzymes .It could catalyse reversible hydration of carbon dioxide. The reaction is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. Fifteen CA isoforms have been reported so far. They have different patterns of tissue-specific expression and physiologic roles. Some CAs may serve as markers for tumours and hypoxia. CA XIV is a polypeptide consisting of an extracellular N-terminal catalytic domain, a membrane-spanning segment and a short intracellular C- terminal segment with several potential phosphorylation sites. A subset of CAs lack CA activity due to point mutations but retain esterase function. CA14 is widely expressed in the central nervous system
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-11304R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11304R-A750
Lokale Artikelnummer::
BOSSBS-11304R-A750
Beschreibung:
Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide-binding consensus sequences. Four of the five RFC genes (including RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC1 is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during FAS-mediated apoptosis. In addition, phosphorylation of the PCNA binding domain of RFC1 by Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibits DNA synthesis. The human RFC1 gene maps to chromosome 4p14 and encodes the RFC1 subunit.
VE:
1 * 100 µl
Artikel-Nr:
(USBI133439)
Lieferant:
US Biological
Hersteller-Artikelnummer::
133439
Lokale Artikelnummer::
USBI133439
Beschreibung:
Anti-SLC25A24 Mouse Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(PRSIPM-5207)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
PM-5207
Lokale Artikelnummer::
PRSIPM-5207
Beschreibung:
ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
VE:
1 * 100 µG
Lieferant:
MACHEREY-NAGEL
Beschreibung:
Die VISOCOLOR® Testkits sind in VISOCOLOR® alpha, ECO und HE unterteilt. Dabei besitzt jede Produktlinie ihre eigenen Vorzüge, um einen maßgeschneiderten Test für jede Anwendung und jeden Anwender zu bieten.
Artikel-Nr:
(662-0368)
Lieferant:
WTW
Hersteller-Artikelnummer::
120200
Lokale Artikelnummer::
WTWA120200
Beschreibung:
Standardlösungen zur Kalibrierung enthalten pro Liter 10 g des zu messenden Ions.
VE:
1 * 1 L
Artikel-Nr:
(PRSI4123)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4123
Lokale Artikelnummer::
PRSI4123
Beschreibung:
STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.
VE:
1 * 100 µG
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 2869-83-2
Artikel-Nr:
(PRSIPM-4911)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
PM-4911
Lokale Artikelnummer::
PRSIPM-4911
Beschreibung:
ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
VE:
1 * 100 µG
Artikel-Nr:
(705-3041)
Lieferant:
Hach
Hersteller-Artikelnummer::
LCK427
Lokale Artikelnummer::
HACHLCK427
Beschreibung:
Für maximale Sicherheit vordosierte Reagenzien.
VE:
1 * 24 Tests
Artikel-Nr:
(USBIC2400-10R)
Lieferant:
US Biological
Hersteller-Artikelnummer::
C2400-10R
Lokale Artikelnummer::
USBIC2400-10R
Beschreibung:
Anti-PTPRC Mouse Monoclonal Antibody (FITC (Fluorescein))
VE:
1 * 50 µG
Artikel-Nr:
(ABNOMAB1433)
Lieferant:
Abnova
Hersteller-Artikelnummer::
MAB1433
Lokale Artikelnummer::
ABNOMAB1433
Beschreibung:
Mouse monoclonal antibody raised against native CD3E.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-1599R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1599R-CY3
Lokale Artikelnummer::
BOSSBS-1599R-CY3
Beschreibung:
Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI4111)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4111
Lokale Artikelnummer::
PRSI4111
Beschreibung:
ORAI2 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3.
VE:
1 * 100 µG
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
