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L(-)-Glutathion+(oxidierte+Form)
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L(-)-Glutathion+(oxidierte+Form)
Artikel-Nr:
(BOSSBS-0018R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0018R-FITC
Lokale Artikelnummer::
BOSSBS-0018R-FITC
Beschreibung:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2060R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2060R-A555
Lokale Artikelnummer::
BOSSBS-2060R-A555
Beschreibung:
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7780R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7780R-A350
Lokale Artikelnummer::
BOSSBS-7780R-A350
Beschreibung:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2060R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2060R-A488
Lokale Artikelnummer::
BOSSBS-2060R-A488
Beschreibung:
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5337R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5337R-A350
Lokale Artikelnummer::
BOSSBS-5337R-A350
Beschreibung:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5036R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5036R-A488
Lokale Artikelnummer::
BOSSBS-5036R-A488
Beschreibung:
Apolipoprotein C-II (apoCII) is in found in chylomicrons (large lipoprotein particles absorbed from the gastrointestinal tract) and VLDL (large lipoproteins that are broken down to eventually form LDL). ApoCII activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5036R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5036R-A350
Lokale Artikelnummer::
BOSSBS-5036R-A350
Beschreibung:
Apolipoprotein C-II (apoCII) is in found in chylomicrons (large lipoprotein particles absorbed from the gastrointestinal tract) and VLDL (large lipoproteins that are broken down to eventually form LDL). ApoCII activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5334R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5334R-A555
Lokale Artikelnummer::
BOSSBS-5334R-A555
Beschreibung:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4208R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4208R-HRP
Lokale Artikelnummer::
BOSSBS-4208R-HRP
Beschreibung:
Cullin 1 may be involved in the degradation of positive cell cycle regulators (for example G1 cyclins in yeast). Human cullin 1 forms a complex with Skp1 and the F box protein Skp2, which is thought to play a role in the ubiquitination of G1 regulatory proteins, as its homolog does in yeast.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8329R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8329R-A750
Lokale Artikelnummer::
BOSSBS-8329R-A750
Beschreibung:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0417R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0417R-A647
Lokale Artikelnummer::
BOSSBS-0417R-A647
Beschreibung:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9668R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9668R-HRP
Lokale Artikelnummer::
BOSSBS-9668R-HRP
Beschreibung:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11236R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11236R-A555
Lokale Artikelnummer::
BOSSBS-11236R-A555
Beschreibung:
During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8338R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8338R
Lokale Artikelnummer::
BOSSBS-8338R
Beschreibung:
Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11236R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11236R-FITC
Lokale Artikelnummer::
BOSSBS-11236R-FITC
Beschreibung:
During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11236R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11236R-CY3
Lokale Artikelnummer::
BOSSBS-11236R-CY3
Beschreibung:
During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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