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(2R)-1-Azabicyclo[2.2.2]octane-2-carbonitrile
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(2R)-1-Azabicyclo[2.2.2]octane-2-carbonitrile
Artikel-Nr:
(BOSSBS-13536R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13536R-A750
Lokale Artikelnummer::
BOSSBS-13536R-A750
Beschreibung:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13536R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13536R-A555
Lokale Artikelnummer::
BOSSBS-13536R-A555
Beschreibung:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13536R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13536R-A680
Lokale Artikelnummer::
BOSSBS-13536R-A680
Beschreibung:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
VE:
1 * 100 µl
Artikel-Nr:
(04-12-0001-100)
Lieferant:
Novabiochem (Part of Merck)
Hersteller-Artikelnummer::
8.53000.0100
Lokale Artikelnummer::
NOVA8.53000.0100
Beschreibung:
N-Boc-glycin (Boc-Gly-OH)
VE:
1 * 100 g
Lieferant:
Bernd Kraft
Beschreibung:
Dibutylamin 1 mol/l chlorobenzene Isocyanate reaction
Lieferant:
Alfa Aesar
Beschreibung:
(±)-2-Butanol, wasserfrei 99%
Lieferant:
Sigma-Aldrich
Beschreibung:
Glycin (H-Gly-OH), Sigma-Aldrich®
Lieferant:
Bernd Kraft
Beschreibung:
Dibutylamin 0.01 mol/l (0.01 N) in DMF
Lieferant:
Bernd Kraft
Beschreibung:
Dibutylamin 1.5 mol/l (1.5 N) in Methanol
Lieferant:
Alfa Aesar
Beschreibung:
Amiodarone hydrochloride
Artikel-Nr:
(STRE15-5812-50G)
Lieferant:
Strem Chemicals, Inc.
Hersteller-Artikelnummer::
15-5812-50G
Lokale Artikelnummer::
STRE15-5812-50G
Beschreibung:
Phosphine
VE:
1 * 50 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Bernd Kraft
Beschreibung:
Dibutylamin 1% in DMF
Lieferant:
Sigma-Aldrich
Beschreibung:
Nɑ-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan ≥97,0% (durch HPLC), Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
TRITON™ X-114 (Polyethylenglycol-[4-(1,1,3,3-tetramethylbutyl)phenyl]ether, Polyethylenglycol-tert-octylphenylether), Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
TRITON™ X-114 (Polyethylenglycol-[4-(1,1,3,3-tetramethylbutyl)phenyl]ether, Polyethylenglycol-tert-octylphenylether), Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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