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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
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Artikel-Nr:
(PRSI76-504)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-504
Lokale Artikelnummer::
PRSI76-504
Beschreibung:
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI76-289)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-289
Lokale Artikelnummer::
PRSI76-289
Beschreibung:
The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3 epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI76-296)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-296
Lokale Artikelnummer::
PRSI76-296
Beschreibung:
The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3 epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI92-031)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-031
Lokale Artikelnummer::
PRSI92-031
Beschreibung:
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator and is capable of enhancing ER-mediated transcription.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI33-586)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-586
Lokale Artikelnummer::
PRSI33-586
Beschreibung:
Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt].
VE:
1 * 100 µG
New Product
Lieferant:
Molekula
Beschreibung:
L(-)-Glutathion (reduzierte Form)
Artikel-Nr:
(PRSI90-464)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-464
Lokale Artikelnummer::
PRSI90-464
Beschreibung:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-413)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-413
Lokale Artikelnummer::
PRSI96-413
Beschreibung:
Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-? (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).
VE:
1 * 200 µG
Artikel-Nr:
(PRSI27-841)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-841
Lokale Artikelnummer::
PRSI27-841
Beschreibung:
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-981)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-981
Lokale Artikelnummer::
PRSI29-981
Beschreibung:
FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-898)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-898
Lokale Artikelnummer::
PRSI79-898
Beschreibung:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-510)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-510
Lokale Artikelnummer::
PRSI90-510
Beschreibung:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
VE:
1 * 10 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
L(-)-Glutathion (reduzierte Form), Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
L(-)-Glutathion (reduzierte Form), Sigma-Aldrich®
Artikel-Nr:
(734-1273)
Lieferant:
Corning
Hersteller-Artikelnummer::
354259
Lokale Artikelnummer::
BDAA354259
Beschreibung:
Laminin, ein Hauptbestandteil der Basalmembran, besitzt eine Vielzahl biologischer Aktivitätsfunktionen, einschließlich Verbesserung von Adhäsion, Migration, Wachstum, Differenzierung und Neuritauswuchs von Zellen. Es kann als dünne Schicht auf die Gewebekulturoberflächen aufgetragen werden oder Nährmedien als löslicher Zusatzstoff hinzugefügt werden. Der hochkonzentrierte Laminin/Entactin-Komplex ist eine spezielle Zusammensetzung, der für dreidimensionale (3D) Nährmedien entwickelt wurde.
VE:
1 * 10,5 mg
Artikel-Nr:
(PRSI76-927)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-927
Lokale Artikelnummer::
PRSI76-927
Beschreibung:
The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDa type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. CD127 binds with CD132 (gamma c) to forms the IL-7 receptor that is expressed on mature T cells and immature B cells. Since CD127 expression is downregulated in Treg cells, it can be used as a marker for differentiating them from common T cells. The binding of the RDR5 antibody can be blocked by pre-incubating the cells with human IL-7.
VE:
1 * 100 Tests
New Product
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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