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Potassium+hexacyanocobaltate(III)
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Potassium+hexacyanocobaltate(III)
Artikel-Nr:
(USBI043639-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
043639-BIOTIN
Lokale Artikelnummer::
USBI043639-BIOTIN
Beschreibung:
Anti-UQCRB Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(USBIC2398-03F)
Lieferant:
US Biological
Hersteller-Artikelnummer::
C2398-03F
Lokale Artikelnummer::
USBIC2398-03F
Beschreibung:
Anti-CD44 Mouse Monoclonal Antibody [clone: BU52]
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-1803R-PE)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1803R-PE
Lokale Artikelnummer::
BOSSBS-1803R-PE
Beschreibung:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11754R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11754R-A647
Lokale Artikelnummer::
BOSSBS-11754R-A647
Beschreibung:
SCGN is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11754R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11754R-A680
Lokale Artikelnummer::
BOSSBS-11754R-A680
Beschreibung:
SCGN is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0836R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0836R-CY5.5
Lokale Artikelnummer::
BOSSBS-0836R-CY5.5
Beschreibung:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1803R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1803R-A750
Lokale Artikelnummer::
BOSSBS-1803R-A750
Beschreibung:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1803R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1803R-HRP
Lokale Artikelnummer::
BOSSBS-1803R-HRP
Beschreibung:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5933R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5933R-CY3
Lokale Artikelnummer::
BOSSBS-5933R-CY3
Beschreibung:
KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents.
VE:
1 * 100 µl
Lieferant:
Molecular Devices
Beschreibung:
EarlyTox™ Cell Viability Assay Kits are a family of fluorescence-based reagents for the assessment of cell viability, cell proliferation, and various apoptosis events using mammalian cells. Optimised for use with microplate readers, these assay kits employ a no-wash, homogeneous assay protocol that enables characterisation of a full concentration-response profile of test compounds.
Artikel-Nr:
(BOSSBS-0533R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0533R
Lokale Artikelnummer::
BOSSBS-0533R
Beschreibung:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Calcein-AM ist eine nicht fluoreszierende, membranpermeable Verbindung. Esteraseaktivität in den Zytoplasmen lebensfähiger Zellen wandelt Calcein-AM in die grün fluoreszierende, membranimpermeable Verbindung Calcein um, welche in lebensfähigen Zellen mit intakten Plasmamembranen eingeschlossen wird. Das Zellviabilitäts-/Zytotoxizitäts-Assay-Kit für lebende und tote Tierzellen paart das Calcein-AM mit dem Lebendfarbstoff Ethidium-Homodimer-III zur Quantifizierung von lebenden und toten Zellen.
Artikel-Nr:
(BOSSBS-5933R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5933R-HRP
Lokale Artikelnummer::
BOSSBS-5933R-HRP
Beschreibung:
KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6719R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6719R-HRP
Lokale Artikelnummer::
BOSSBS-6719R-HRP
Beschreibung:
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6719R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6719R-A488
Lokale Artikelnummer::
BOSSBS-6719R-A488
Beschreibung:
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4775R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4775R-A680
Lokale Artikelnummer::
BOSSBS-4775R-A680
Beschreibung:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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