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Soluble+gamma-cyclodextrin+polymer+crosslinked+with+epichlorohydr
Artikel-Nr:
(PRSI90-472)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-472
Lokale Artikelnummer::
PRSI90-472
Beschreibung:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI76-835)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-835
Lokale Artikelnummer::
PRSI76-835
Beschreibung:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gamma delta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI33-148)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-148
Lokale Artikelnummer::
PRSI33-148
Beschreibung:
This antibody recognises a protein of 75 kDa, identified as the mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. The antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI77-175)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-175
Lokale Artikelnummer::
PRSI77-175
Beschreibung:
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro/in vivo.
VE:
1 * 0,5 mg
New Product
Artikel-Nr:
(PRSI33-082)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-082
Lokale Artikelnummer::
PRSI33-082
Beschreibung:
This antibody recognises the epsilon-chain of CD3 (CD3e), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16 to 28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the Tcell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the Tcell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the Tcell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the Tcell surface. CD3 antigen is a highly specific marker for Tcells, and is present in majority of Tcell neoplasms.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI91-747)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-747
Lokale Artikelnummer::
PRSI91-747
Beschreibung:
Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Coupleing activate of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-505)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-505
Lokale Artikelnummer::
PRSI76-505
Beschreibung:
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI76-284)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-284
Lokale Artikelnummer::
PRSI76-284
Beschreibung:
The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3 epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI76-500)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-500
Lokale Artikelnummer::
PRSI76-500
Beschreibung:
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI33-622)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-622
Lokale Artikelnummer::
PRSI33-622
Beschreibung:
Beta Catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. b-Catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to gamma-Catenin, also known as plakoglobin. b-Catenin is widely expressed in many tissues. In cardiac muscle, it localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte. [Wiki].
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI28-638)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-638
Lokale Artikelnummer::
PRSI28-638
Beschreibung:
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI50-215)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-215
Lokale Artikelnummer::
PRSI50-215
Beschreibung:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI2465)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2465
Lokale Artikelnummer::
PRSI2465
Beschreibung:
IL-21 Antibody: A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
VE:
1 * 100 µG
Lieferant:
Alfa Aesar
Beschreibung:
N-Methyl-2-pyrrolidon (NMP), wasserfrei ≥99,5%
Artikel-Nr:
(PRSI92-637)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-637
Lokale Artikelnummer::
PRSI92-637
Beschreibung:
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF- gamma , which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the binding and neutralizing properties of the binding proteins. The IL-18 BP isoforms b and d lack a complete Ig domain. The expression of IL-18 and the IL-18BP are unidentified in immune tissues such as the spleen, but also in nonimmune cells including keratinocytes.
VE:
1 * 50 µG
Lieferant:
MEMMERT
Beschreibung:
Alternative Lichtkassetten mit 6 UV-Lampen (Bereich von 315 bis 400 nm), zwei Kassetten, ICH750L
Preis auf Anfrage
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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