Suche >
Soluble+gamma-cyclodextrin+polymer+crosslinked+with+epichlorohydr
Drucken
Sie suchten nach:
92 239 results were found
Soluble+gamma-cyclodextrin+polymer+crosslinked+with+epichlorohydr
Artikel-Nr:
(BOSSBS-12225R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12225R-A750
Lokale Artikelnummer::
BOSSBS-12225R-A750
Beschreibung:
ZNF843 is a 348 amino acid protein that is encoded by a gene which maps to chromosome 16. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterised by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16 through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumour growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. The ZNF843 gene product has been provisionally designated MGC46336 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11732R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11732R-A680
Lokale Artikelnummer::
BOSSBS-11732R-A680
Beschreibung:
Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25% sequence homology with PrP. Dpl is characterised by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11806R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11806R-A750
Lokale Artikelnummer::
BOSSBS-11806R-A750
Beschreibung:
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterised by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11628R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11628R-A750
Lokale Artikelnummer::
BOSSBS-11628R-A750
Beschreibung:
Odorant receptor (Potential). May be involved in taste perception.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0633R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0633R-A488
Lokale Artikelnummer::
BOSSBS-0633R-A488
Beschreibung:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10358R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10358R-HRP
Lokale Artikelnummer::
BOSSBS-10358R-HRP
Beschreibung:
9 is a transmembrane glycoprotein that is selectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2039R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2039R-HRP
Lokale Artikelnummer::
BOSSBS-2039R-HRP
Beschreibung:
GRGDS
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9387R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9387R-CY5.5
Lokale Artikelnummer::
BOSSBS-9387R-CY5.5
Beschreibung:
LRSAM1 is an E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivation of the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. It selectively regulates cell adhesion molecules and plays a role in receptor endocytosis and viral budding. LRSAM1 contains a RING-type zinc finger, 5 leucine-rich repeats and 1 SAM (sterile alpha motif) domain. The coiled coil domains interact with the SB domain of TSG101. The PTAP motifs mediate the binding to UEV domains. There are 3 isoforms produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3088R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3088R-CY3
Lokale Artikelnummer::
BOSSBS-3088R-CY3
Beschreibung:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0166R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0166R-A680
Lokale Artikelnummer::
BOSSBS-0166R-A680
Beschreibung:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13474R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13474R-A680
Lokale Artikelnummer::
BOSSBS-13474R-A680
Beschreibung:
During fertilization in mammals, the sperm activates the egg by causing an increase in the level of free cytoplasmic calcium concentration. This increased calcium concentration induces a characteristic series of oscillations that trigger egg activation and early embryo development. A hamster protein named oscillin is thought to be involved in this pathway. The enzyme glucosamine-6-phosphate isomerase (GNPI) or deaminase (GNPDA1) and the related protein GNPDA2 are the human homologs of hamster oscillin. GNPDA1 and GNPDA2 catalyze the conversion of GNP to fructose-6-phosphate and ammonia. Both proteins exist as homohexamers and are ubiquitously expressed with highest expression in testis, ovary and heart. Three isoforms of GNPDA2 are expressed due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2743R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2743R-A680
Lokale Artikelnummer::
BOSSBS-2743R-A680
Beschreibung:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13500R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13500R-A680
Lokale Artikelnummer::
BOSSBS-13500R-A680
Beschreibung:
GPATCH3
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15141R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15141R-A488
Lokale Artikelnummer::
BOSSBS-15141R-A488
Beschreibung:
C22orf45
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15475R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15475R-A488
Lokale Artikelnummer::
BOSSBS-15475R-A488
Beschreibung:
HHCM is a 467 amino acid protein that has oncogenic transforming capabilities on a variety of different cell lines. When HHCM was transfected into BRL-1 (Buffalo rat liver) or NIH3T3 cells, the cells exhibited significant morphological changes, anchorage independent growth and loss of contact inhibition. When the cells were inoculated into rats and mice, they became highly tumorigenic. HHCM gene-related DNA sequences were found in at least nineteen hepatomas of Asian origin. The gene encoding HHCM maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15551R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15551R-CY3
Lokale Artikelnummer::
BOSSBS-15551R-CY3
Beschreibung:
IFI44L.
VE:
1 * 100 µl
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
