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3-Brom-2-fluor-5-methylphenylborons\\\\u00E4ure
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3-Brom-2-fluor-5-methylphenylborons\\\\u00E4ure
Artikel-Nr:
(BOSSBS-1736R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1736R-A488
Lokale Artikelnummer::
BOSSBS-1736R-A488
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5453R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5453R-HRP
Lokale Artikelnummer::
BOSSBS-5453R-HRP
Beschreibung:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1361R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1361R-CY5
Lokale Artikelnummer::
BOSSBS-1361R-CY5
Beschreibung:
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF1B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
VE:
1 * 100 µl
Artikel-Nr:
(PIER89802)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
89802
Lokale Artikelnummer::
PIER89802
Beschreibung:
The I-PER Insect Cell Protein Extraction Reagent enables gentle and effective extraction of soluble protein from baculovirus-infected insect cells grown in suspension or monolayer culture. The baculovirus insect cell expression system is an efficient and popular system for production of recombinant (eukaryotic) proteins in cell culture. Proteins expressed in baculoviral systems can be used for structural analyses, biochemical assays and a variety of other applications. I-PER Reagent maintains functionality of extracted proteins and is directly compatible with downstream applications such as protein assays, Western blotting and 6xHis-tagged protein purification.
VE:
1 * 250 mL
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Rat Monoclonal Antibody [clone: XMG1.2] (APC (Allophycocyanin)/Cy7®)
Artikel-Nr:
(BLEG505836)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
505836
Lokale Artikelnummer::
BLEG505836
Beschreibung:
Anti-IFN-gamma Rat Monoclonal Antibody [clone: XMG1.2] (Brilliant Violet® 711)
VE:
1 * 50 µG
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(4330-100)
Lieferant:
Merck Millipore (Calbiochem)
Hersteller-Artikelnummer::
4330-100
Lokale Artikelnummer::
CALB4330-100
Beschreibung:
L(+)-Leucin, Millipore®
VE:
1 * 100 g
Artikel-Nr:
(BLEG505840)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
505840
Lokale Artikelnummer::
BLEG505840
Beschreibung:
Anti-IFN-gamma Rat Monoclonal Antibody [clone: XMG1.2] (Brilliant Violet® 605)
VE:
1 * 50 µG
This is a MarketSource item. Additional charges may apply
Lieferant:
Biotium
Beschreibung:
Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Mouse Monoclonal Antibody [clone: B27] (PerCP (Peridinin-Chlorophyll Protein Complex)/Cy5.5®)
Artikel-Nr:
(BLEG502540)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
502540
Lokale Artikelnummer::
BLEG502540
Beschreibung:
Anti-IFN-gamma Mouse Monoclonal Antibody [clone: 4S.B3] (Brilliant Violet® 711)
VE:
1 * 100 Tests
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(113-2806)
Lieferant:
Thermo Fisher Scientific
Hersteller-Artikelnummer::
6710-2000
Lokale Artikelnummer::
NALG6710-2000
Beschreibung:
Acryl, transparent, Stärke: 9 mm
VE:
1 * 1 ST
Lieferant:
Corning Life Science
Beschreibung:
FBS is a commonly used cell culture media supplement which helps sustain cell growth and satisfy metabolic requirements.
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Monokine induced by gamma interferon (MIG or CXCL9) is a T cell chemoattractant during neuroinflammatory events. MIG production is stimulated by interferon gamma (IFNɣ) and signals through the chemokine receptor CXCR3.
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Mouse Monoclonal Antibody [clone: B27] (APC (Allophycocyanin)/Cy7®)
Artikel-Nr:
(PRSI92-246)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-246
Lokale Artikelnummer::
PRSI92-246
Beschreibung:
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon- gamma (IFN- gamma ) or type II interferon that plays an important role in activating the macrophages or other cells.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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