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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
Artikel-Nr:
(BOSSBS-4005R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-CY7
Lokale Artikelnummer::
BOSSBS-4005R-CY7
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI32-173)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
32-173
Lokale Artikelnummer::
PRSI32-173
Beschreibung:
Interferon-g (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
VE:
1 * 100 µG
Artikel-Nr:
(ROCK610-453-C46)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
610-453-C46
Lokale Artikelnummer::
ROCK610-453-C46
Beschreibung:
The emission spectra for this ATTO conjugate matches the principle output wavelengths of most common fluorescence instrumentation.
VE:
1 * 500 µG
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Rat Monoclonal Antibody [clone: AN-18] (Ultra-LEAF™)
Artikel-Nr:
(MOLE25579154-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
25579154-25G
Lokale Artikelnummer::
MOLE25579154-25G
Beschreibung:
4,4′-Bipyridin
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Sigma-Aldrich
Beschreibung:
Phenol, Kristalle, Sigma-Aldrich®
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Mouse Monoclonal Antibody [clone: MD-1] (Ultra-LEAF™)
Artikel-Nr:
(PRSI77-030)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-030
Lokale Artikelnummer::
PRSI77-030
Beschreibung:
The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI77-047)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-047
Lokale Artikelnummer::
PRSI77-047
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI77-039)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-039
Lokale Artikelnummer::
PRSI77-039
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,1 mg
New Product
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-TCR gamma/delta Armenian hamster Monoclonal Antibody [clone: GL3] (Alexa Fluor® 647)
Artikel-Nr:
(SPCME1040-500GM)
Lieferant:
Spectrum Chemical
Hersteller-Artikelnummer::
E1040-500GM
Lokale Artikelnummer::
SPCME1040-500GM
Beschreibung:
(Ethylenedinitrilo)tetraacetic Acid, Powder, Reagent, ACS, is generally abbreviated as EDTA, a colorless, water soluble aminopolycarboxylic acid and solid. It is used by many industries and in the laboratory for applications ranging from a sequestering agent to chelation therapy. As an ACS grade Reagent, this Spectrum Chemical manufactured compound is used as the quality standard against which other substances are graded and has met the toughest regulatory standards for quality and pureness.
VE:
1 * 500 g
Artikel-Nr:
(PRSI33-983)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-983
Lokale Artikelnummer::
PRSI33-983
Beschreibung:
Actins are a family of proteins which are highly conserved and play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. [RefSeq].
VE:
1 * 100 µG
New Product
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon gamma (IFN-ɣ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and natural killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
Artikel-Nr:
(BOSSBS-1935R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1935R-A680
Lokale Artikelnummer::
BOSSBS-1935R-A680
Beschreibung:
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0836R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0836R-A647
Lokale Artikelnummer::
BOSSBS-0836R-A647
Beschreibung:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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