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beta-Methyl-gamma-octanolactone+(mixture+of+isomers)
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beta-Methyl-gamma-octanolactone+(mixture+of+isomers)
Artikel-Nr:
(BOSSBS-0169R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0169R-A750
Lokale Artikelnummer::
BOSSBS-0169R-A750
Beschreibung:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1380R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1380R-A647
Lokale Artikelnummer::
BOSSBS-1380R-A647
Beschreibung:
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilisation and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0074R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0074R-A647
Lokale Artikelnummer::
BOSSBS-0074R-A647
Beschreibung:
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0074R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0074R-A488
Lokale Artikelnummer::
BOSSBS-0074R-A488
Beschreibung:
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1175R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1175R-HRP
Lokale Artikelnummer::
BOSSBS-1175R-HRP
Beschreibung:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15522R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15522R-A555
Lokale Artikelnummer::
BOSSBS-15522R-A555
Beschreibung:
IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1175R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1175R-A555
Lokale Artikelnummer::
BOSSBS-1175R-A555
Beschreibung:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0657R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0657R-A555
Lokale Artikelnummer::
BOSSBS-0657R-A555
Beschreibung:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
VE:
1 * 100 µl
Artikel-Nr:
(BNUM1208-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM1208-50
Lokale Artikelnummer::
BTIUBNUM1208-50
Beschreibung:
This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
VE:
1 * 50 µl
Artikel-Nr:
(APOSOR14727-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR14727-1G
Lokale Artikelnummer::
APOSOR14727-1G
Beschreibung:
H-β-(3-Benzothienyl)-Ala-OH 95+%
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-4538R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4538R-A680
Lokale Artikelnummer::
BOSSBS-4538R-A680
Beschreibung:
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3114R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3114R-CY7
Lokale Artikelnummer::
BOSSBS-3114R-CY7
Beschreibung:
Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases. Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, likely indirectly, Reelin-induced signaling during neural cortex development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0018R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0018R-A488
Lokale Artikelnummer::
BOSSBS-0018R-A488
Beschreibung:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4616R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4616R-A680
Lokale Artikelnummer::
BOSSBS-4616R-A680
Beschreibung:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
VE:
1 * 100 µl
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin 1 (IL-1), interleukin 8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-gamma-activated macrophages, MIF stimulates nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α) secretion.
Artikel-Nr:
(BOSSBS-3114R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3114R-CY5
Lokale Artikelnummer::
BOSSBS-3114R-CY5
Beschreibung:
Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases. Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, likely indirectly, Reelin-induced signaling during neural cortex development.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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