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Methyl-4\\\'-brombiphenyl-4-carboxylat
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Methyl-4\\\'-brombiphenyl-4-carboxylat
Artikel-Nr:
(BOSSBS-8405R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8405R-A555
Lokale Artikelnummer::
BOSSBS-8405R-A555
Beschreibung:
GFOD2 is a 385 amino acid secreted protein of the extracellular matrix that belongs to the gfo/idh/mocA family. Existing as two alternatively spliced isoforms, GFOD2 enhances matrix assembly and is encoded by a gene that maps to human chromosome 16q22.1. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3112R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3112R-A350
Lokale Artikelnummer::
BOSSBS-3112R-A350
Beschreibung:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9407R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9407R-CY5
Lokale Artikelnummer::
BOSSBS-9407R-CY5
Beschreibung:
The small leucine-rich proteoglycan (SLRP) family of proteins contains various proteins such as Decorin, Biglycan, Fibromodulin, Keratocan, Lumican, Osteoadherin and Osteoglycin. These proteins all have similar functions as they all mediate extracellular matrix organization and act as binding partners of TGF beta. Osteoglycin, which also may be designated osteoinductive factor (OIF), is a secreted protein detected in bone tissues. Osteoglycin induces the formation of bone in conjunction with either TGF-beta-1 or TGF-beta-2. The precursor form of the OGN gene product, designated Mimecan, is subject to in situ proteolytic cleavage to yield the mature Osteoglycin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6639R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6639R
Lokale Artikelnummer::
BOSSBS-6639R
Beschreibung:
Anti-BMPR1B Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12527R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12527R-A488
Lokale Artikelnummer::
BOSSBS-12527R-A488
Beschreibung:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3069R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3069R-HRP
Lokale Artikelnummer::
BOSSBS-3069R-HRP
Beschreibung:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13260R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13260R-A680
Lokale Artikelnummer::
BOSSBS-13260R-A680
Beschreibung:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1447R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1447R-HRP
Lokale Artikelnummer::
BOSSBS-1447R-HRP
Beschreibung:
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12465R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12465R-A488
Lokale Artikelnummer::
BOSSBS-12465R-A488
Beschreibung:
Syntaxins were originally thought to be docking proteins, but have more recently been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various proteins involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25 (synaptosomal-associated protein of 25kDa), SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs (also designated synaptobrevins), including VAMP-1 and VAMP-2, and synaptotagmin, a protein that may function as an inhibitor of exocytosis, are vesicular proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5777R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5777R-CY5.5
Lokale Artikelnummer::
BOSSBS-5777R-CY5.5
Beschreibung:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9074R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9074R-FITC
Lokale Artikelnummer::
BOSSBS-9074R-FITC
Beschreibung:
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13527R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13527R-A680
Lokale Artikelnummer::
BOSSBS-13527R-A680
Beschreibung:
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an ancient evolutionarily mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs have seven membrane-spanning domains and the extracellular domains are often glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR26 (G-protein coupled receptor 26) is a 337 amino acid protein that is primarily expressed in regions of the brain. GPR26 is characterized as an orphan? G protein-coupled receptor, which is a receptor that binds an unidentified natural ligand. Due to evidence of GPR26 being downregulated in glioblastomas, it has been suggested that GPR26 may be a suppressor of early glioma development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1348R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1348R-HRP
Lokale Artikelnummer::
BOSSBS-1348R-HRP
Beschreibung:
Potentiates but cannot initiate FAS-induced apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6995R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6995R-HRP
Lokale Artikelnummer::
BOSSBS-6995R-HRP
Beschreibung:
Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15037R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15037R-CY5
Lokale Artikelnummer::
BOSSBS-15037R-CY5
Beschreibung:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf172 gene product has been provisionally designated C1orf172 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3349R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3349R-A647
Lokale Artikelnummer::
BOSSBS-3349R-A647
Beschreibung:
postsynaptic density protein 95 is a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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