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3-(Trifluoromethyl)quinoline
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3-(Trifluoromethyl)quinoline
Artikel-Nr:
(BOSSBS-15209R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15209R-CY7
Lokale Artikelnummer::
BOSSBS-15209R-CY7
Beschreibung:
C5orf52
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11787R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11787R-A350
Lokale Artikelnummer::
BOSSBS-11787R-A350
Beschreibung:
Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson’s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson’s disease, Alzheimer’s disease and several other neurodegenerative illnesses.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1975R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1975R-CY7
Lokale Artikelnummer::
BOSSBS-1975R-CY7
Beschreibung:
Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6255R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6255R-CY3
Lokale Artikelnummer::
BOSSBS-6255R-CY3
Beschreibung:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7066R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7066R-CY7
Lokale Artikelnummer::
BOSSBS-7066R-CY7
Beschreibung:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase /c-Jun N-terminal kinase (SAPK/JNK)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9668R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9668R-A647
Lokale Artikelnummer::
BOSSBS-9668R-A647
Beschreibung:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5034R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5034R
Lokale Artikelnummer::
BOSSBS-5034R
Beschreibung:
Anti-APOA2 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11791R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11791R-A350
Lokale Artikelnummer::
BOSSBS-11791R-A350
Beschreibung:
G protein-coupled receptors (GPRs or GPCRs), are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR143, also designated ocular albinism type 1 protein (OA1), is detected exclusively in pigment cells. OA1, which is a multi-pass membrane protein, is a melanosomal protein expressed primarily in pigment cells. Defects in the gene encoding for OA1 cause ocular albinism, an X-linked disorder mainly characterized by retinal hypopigmentation and visual impairment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2436R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2436R-FITC
Lokale Artikelnummer::
BOSSBS-2436R-FITC
Beschreibung:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2247R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2247R-CY3
Lokale Artikelnummer::
BOSSBS-2247R-CY3
Beschreibung:
AHA3
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11126R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11126R-A647
Lokale Artikelnummer::
BOSSBS-11126R-A647
Beschreibung:
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12350R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12350R-A350
Lokale Artikelnummer::
BOSSBS-12350R-A350
Beschreibung:
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and in the control of gene expression. MIXL1 (Mix1 homeobox-like 1), also known as MIXL, is a 232 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in lymph tissues, MIXL1 functions as a transcription factor that plays an essential role in axial mesendoderm morphogenesis and endoderm formation and is also required for cellular differentiation during blood development. Additionally, MIXL1 is involved in maturation of heart and gut tissue during embryogenesis and may also act as a negative regulator of brachyury expression. Overexpression of MIXL1 is associated with non-Hodgkin and Hodgkin lymphomas, suggesting a role in carcinogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7840R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7840R-CY7
Lokale Artikelnummer::
BOSSBS-7840R-CY7
Beschreibung:
MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11651R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11651R-A488
Lokale Artikelnummer::
BOSSBS-11651R-A488
Beschreibung:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9348R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9348R-A488
Lokale Artikelnummer::
BOSSBS-9348R-A488
Beschreibung:
ACLP2 (acid phosphatase-like 2), also known as UNQ370 or PRO706, is a 480 amino acid secreted protein that functions to catalyze the H2O-dependent conversion of a phosphate monoester to an alcohol and a phosphate. Expressed as two alternatively spliced isoforms, ACPL2 is encoded by a gene that maps to chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2352R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2352R-FITC
Lokale Artikelnummer::
BOSSBS-2352R-FITC
Beschreibung:
Cytochromes P45 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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