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1-Butyl-3-methylimidazolium+hydrogen+sulphate
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1-Butyl-3-methylimidazolium+hydrogen+sulphate
Artikel-Nr:
(BOSSBS-3559R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3559R-A647
Lokale Artikelnummer::
BOSSBS-3559R-A647
Beschreibung:
mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0520R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0520R-A680
Lokale Artikelnummer::
BOSSBS-0520R-A680
Beschreibung:
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8486R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8486R-HRP
Lokale Artikelnummer::
BOSSBS-8486R-HRP
Beschreibung:
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2081R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2081R-CY3
Lokale Artikelnummer::
BOSSBS-2081R-CY3
Beschreibung:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8409R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8409R-A488
Lokale Artikelnummer::
BOSSBS-8409R-A488
Beschreibung:
GLB1L3 is a 653 amino acid protein belonging to the glycosyl hydrolase 35 family. GLB1L3 exists as three alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 11q25. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11629R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11629R-A488
Lokale Artikelnummer::
BOSSBS-11629R-A488
Beschreibung:
Olfactory receptors are G protein-coupled receptors that localize to the cilia of olfactory sensory neurons where they display affinity for and bind to a variety of odor molecules. The genes encoding olfactory receptors comprise the largest family in the human genome. The binding of olfactory receptor proteins to odor molecules triggers a signal transduction that propagates nerve impulses throughout the body, ultimately leading to transmission of the signal to the brain and the subsequent perception of smell. OR10J3 (olfactory receptor 10J3) is a 329 amino acid protein. The gene encoding OR10J3 maps to human chromosome 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8021R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8021R-CY5.5
Lokale Artikelnummer::
BOSSBS-8021R-CY5.5
Beschreibung:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13326R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13326R-A350
Lokale Artikelnummer::
BOSSBS-13326R-A350
Beschreibung:
Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. The LOC390637 gene product has been provisionally designated LOC390637 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8367R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8367R-A647
Lokale Artikelnummer::
BOSSBS-8367R-A647
Beschreibung:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4979R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4979R-CY5.5
Lokale Artikelnummer::
BOSSBS-4979R-CY5.5
Beschreibung:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3362R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3362R-A680
Lokale Artikelnummer::
BOSSBS-3362R-A680
Beschreibung:
Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11815R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11815R-A488
Lokale Artikelnummer::
BOSSBS-11815R-A488
Beschreibung:
Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2330R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2330R-CY5.5
Lokale Artikelnummer::
BOSSBS-2330R-CY5.5
Beschreibung:
RAP2B belongs to a family of RAS-related GTP-binding proteins. RAP proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. However, at their 61st amino acid the glutamine in RAS proteins is replaced by threonine in RAP proteins. RAP2A interacts with phospholipase C, epsilon 1 (PLCE1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13640R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13640R-HRP
Lokale Artikelnummer::
BOSSBS-13640R-HRP
Beschreibung:
Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific receptor sequences. For instance, the GRB family of proteins lack a defined catalytic activity and are entirely composed of SH2 and SH3 domains. Members include GRB2, GRB7, GRB10 (also referred to as GRB-IR), GRB14 and Grap (for GRB2-related adapter protein). While GRB10 and GRB14 are most closely related to GRB7, Grap shares the highest degree of homology with GRB2 exhibiting 59% sequence identity with GRB2. The Grap SH2 domain is capable of binding to the activated stem cell factor receptor, c-Kit and the erythropoietin receptor (EpoR). Grap also associates with the Ras guanine nucleotide exchange factor Sos 1 via its amino terminal SH3 domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3142R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3142R
Lokale Artikelnummer::
BOSSBS-3142R
Beschreibung:
Anti-FOXO1 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6854R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6854R-A750
Lokale Artikelnummer::
BOSSBS-6854R-A750
Beschreibung:
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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