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APPLICHEM
Artikel-Nr:
(BOSSBS-13155R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13155R-CY3
Lokale Artikelnummer::
BOSSBS-13155R-CY3
Beschreibung:
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1956R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1956R-CY5.5
Lokale Artikelnummer::
BOSSBS-1956R-CY5.5
Beschreibung:
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12125R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12125R-HRP
Lokale Artikelnummer::
BOSSBS-12125R-HRP
Beschreibung:
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. SNAT2, also designated ATA2, PRO1068 and SAT2 is encoded by the human gene SLC38A2. The functional role of SNAT2 in the nervous system is unclear. Protein expression is notably enriched in the spinal cord and brain stem nuclei of the auditory system. System A transport proteins are also present in placental tissue. These SNAT proteins may play a significant role in fetal development and inhibition of the transport system has been associated with fetal growth retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3973R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3973R-A750
Lokale Artikelnummer::
BOSSBS-3973R-A750
Beschreibung:
UQCRC2 is a component of the ubiquinol cytochrome c reductase complex (complex III), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-CY3
Lokale Artikelnummer::
BOSSBS-15486R-CY3
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13512R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13512R-A680
Lokale Artikelnummer::
BOSSBS-13512R-A680
Beschreibung:
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR103 is a 455-amino acid protein with highest expression in the brain, retina, trigeminal ganglion, hypothalamus and vestibular nucleus. In peripheral tissues, GPR103 is expressed only in the heart, kidney and testis. GPR103 may regulate adrenal function. A hypothalamic neuropeptide of the RFamide family (26RFa) acts as an endogenous ligand for GPR103.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12193R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12193R-CY3
Lokale Artikelnummer::
BOSSBS-12193R-CY3
Beschreibung:
Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10041R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10041R-A647
Lokale Artikelnummer::
BOSSBS-10041R-A647
Beschreibung:
Glycophorins A, B and C are sialoglycoproteins of the human erythrocyte membrane, which bear the antigenic determinants for the MN, Ss and Gerbich blood groups, respectively. Glycophorins span the membrane once and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. The human Glycophorin A gene maps to chromosome 4q31.21, contains seven exons which are 97% homologous to Glycophorin B, and encodes a 150 amino acid protein. The human Glycophorin B gene maps to chromosome 4q31.21 and encodes a 91 amino acid protein. The human Glycophorin C gene maps to chromosome 2q14.3 and contains four exons. Glycophorin C transcript can generate two protein isoforms. Isoform 1 includes all 4 exons and encodes the full length 128 amino acid protein. Isoform 2 is missing exon 2 and encodes a 109 amino acid protein, which specifies the Yus subtype of the Gerbich phenotype.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15575R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15575R-A350
Lokale Artikelnummer::
BOSSBS-15575R-A350
Beschreibung:
IGKV A18.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2631R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2631R
Lokale Artikelnummer::
BOSSBS-2631R
Beschreibung:
IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12242R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12242R-A488
Lokale Artikelnummer::
BOSSBS-12242R-A488
Beschreibung:
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1369R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1369R-A555
Lokale Artikelnummer::
BOSSBS-1369R-A555
Beschreibung:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6096R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6096R-FITC
Lokale Artikelnummer::
BOSSBS-6096R-FITC
Beschreibung:
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12036R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12036R-A555
Lokale Artikelnummer::
BOSSBS-12036R-A555
Beschreibung:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8196R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8196R-A488
Lokale Artikelnummer::
BOSSBS-8196R-A488
Beschreibung:
FAM55D
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8133R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8133R-A350
Lokale Artikelnummer::
BOSSBS-8133R-A350
Beschreibung:
This gene encodes a protein with filament, myosin tail and ATPase domains. Orthologs of this gene exist in mouse, rat and chimp. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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