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Anti-TFRC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Lieferant: Bioss
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BS-0988R-A488
BOSSBS-0988R-A488EA 893 EUR
BOSSBS-0988R-A488
Anti-TFRC Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antikörper
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: TFRC
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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