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Anti-C1orf124 Rabbit Polyclonal Antibody (Cy3®)

Lieferant: Bioss
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BS-15013R-CY3
BOSSBS-15013R-CY3EA 900 EUR
BOSSBS-15013R-CY3
Anti-C1orf124 Rabbit Polyclonal Antibody (Cy3®)
Antikörper
Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Type: Primary
Antigen: C1orf124
Clonality: Polyclonal
Clone:
Conjugation: Cy3
Public Immunogen Range: 31-130/489
Host: Rabbit
Isotype: IgG
Reactivity:
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