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Anti-FBXO21 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Lieferant: Bioss
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BS-9121R-A647
BOSSBS-9121R-A647EA 893 EUR
BOSSBS-9121R-A647
Anti-FBXO21 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
Antikörper
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: FBXO21
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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