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Anti-CD46 Mouse Monoclonal Antibody (Purified) [clone: 122.2]

Lieferant: Biotium
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BNUB0175-500 BNUB0175-100
BNUB0175-500EA 511 EUR
BNUB0175-500 BNUB0175-100
Anti-CD46 Mouse Monoclonal Antibody (Purified) [clone: 122.2]
Antikörper
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Type: Primary
Antigen: CD46
Clonality: Monoclonal
Clone: 122.2
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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