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3,5-Dimethoxyzimts\u00E4ure
Artikel-Nr:
(BOSSBS-9312R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9312R-CY3
Lokale Artikelnummer::
BOSSBS-9312R-CY3
Beschreibung:
DIP2A, also known as DIP2, is a 1571 amino acid nuclear protein. It is one of three human homologs (DIP2A, DIP2B and DIP2C) of the Drosophila dip2 (disconnected-interacting protein 2) protein. In Drosophila, dip2 interacts with disco, a protein required for neuronal connections in the visual systems of larvae and adults. The closest vertebrate homologs to disco are the basonuclin genes. In mice, DIP2 homologs show restricted expression to the brain. This suggests that, similar to the function of Drosophila dip2, vertebrate DIP2 homologs may play a role in the development of the nervous system. Expressed ubiquitously with highest expression in the brain, DIP2A is thought to function in signaling throughout the central nervous system by providing positional clues for axon patterning and pathfinding. Four isoforms of DIP2A exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8231R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8231R-CY5
Lokale Artikelnummer::
BOSSBS-8231R-CY5
Beschreibung:
The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The FAM104B gene product has been provisionally designated FAM104B pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12009R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12009R-CY7
Lokale Artikelnummer::
BOSSBS-12009R-CY7
Beschreibung:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, whereas the four epsilon subunits display limited distribution.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9244R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9244R-CY5.5
Lokale Artikelnummer::
BOSSBS-9244R-CY5.5
Beschreibung:
Tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein 1 (IFP1), is a 488 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Three isoforms of TRIM34 exist as a result of alternative splicing events. Isoform 1, the most abundant isoform, is highly expressed in placenta, spleen, colon and peripheral blood leukocytes. Studies have shown that Interferon (IFN) stimulation leads to an upregulation of TRIM34. These findings suggest that TRIM34 maybe a downstream effector that mediates IFN activities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12134R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12134R-CY3
Lokale Artikelnummer::
BOSSBS-12134R-CY3
Beschreibung:
The Ca2+/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CaMKI Beta (Ca2+/calmodulin-dependent protein kinase type 1B), also known as PNCK (pregnancy up-regulated non-ubiquitously expressed CaM kinase) or BSTK3, is a 343 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one protein kinase domain. Existing as multiple alternatively spliced isoforms, CaMKI Beta functions to catalyze the ATP-dependent phosphorylation of CaMKI, an event that activates CaMKI activity and may be important for Ca2+-triggered signaling cascades within the cell. The gene encoding CaMKI Beta maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8252R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8252R-A647
Lokale Artikelnummer::
BOSSBS-8252R-A647
Beschreibung:
DDRGK1 (DDRGK domain-containing protein 1), also known as C20orf116, is a 314 amino acid secreted protein. DDRGK1 contains one PCI domain and is expressed as two isoforms produced by alternative splicing. The gene that encodes DDRGK1 maps to human chromosome 20, which represents about 2% of human DNA and consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought to be important for seminal production. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13725R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13725R-HRP
Lokale Artikelnummer::
BOSSBS-13725R-HRP
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated a, b and g, all of which contain multiple tandemly-arranged genes. PCDHB10 (protocadherin b10), also known as PCHB10 or PCDH-b10, is an 800 amino acid protein that is one of 16 proteins in the protocadherin b cluster. Unlike the a and g gene clusters, whose genes are spliced to downstream constant-region exons during transcription, members of the b cluster (such as PCDHB10) do not use constant-region exons to produce mRNAs. As a result, each protocadherin b gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. Localized to the cell membrane, PCDHB10 is a single-pass type I membrane protein that contains six cadherin domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9312R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9312R-A647
Lokale Artikelnummer::
BOSSBS-9312R-A647
Beschreibung:
DIP2A, also known as DIP2, is a 1571 amino acid nuclear protein. It is one of three human homologs (DIP2A, DIP2B and DIP2C) of the Drosophila dip2 (disconnected-interacting protein 2) protein. In Drosophila, dip2 interacts with disco, a protein required for neuronal connections in the visual systems of larvae and adults. The closest vertebrate homologs to disco are the basonuclin genes. In mice, DIP2 homologs show restricted expression to the brain. This suggests that, similar to the function of Drosophila dip2, vertebrate DIP2 homologs may play a role in the development of the nervous system. Expressed ubiquitously with highest expression in the brain, DIP2A is thought to function in signaling throughout the central nervous system by providing positional clues for axon patterning and pathfinding. Four isoforms of DIP2A exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7752R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7752R-A750
Lokale Artikelnummer::
BOSSBS-7752R-A750
Beschreibung:
KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8252R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8252R-CY7
Lokale Artikelnummer::
BOSSBS-8252R-CY7
Beschreibung:
DDRGK1 (DDRGK domain-containing protein 1), also known as C20orf116, is a 314 amino acid secreted protein. DDRGK1 contains one PCI domain and is expressed as two isoforms produced by alternative splicing. The gene that encodes DDRGK1 maps to human chromosome 20, which represents about 2% of human DNA and consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought to be important for seminal production. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12489R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12489R-CY7
Lokale Artikelnummer::
BOSSBS-12489R-CY7
Beschreibung:
APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8540R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8540R-A680
Lokale Artikelnummer::
BOSSBS-8540R-A680
Beschreibung:
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. TSHZ3 (teashirt zinc finger homeobox 3), also known as KIAA1474, TSH3 or ZNF537, is a 1,081 amino acid protein that contains one homeobox DNA-binding domain and five C2H2-type zinc fingers. Localised to the nucleus, TSHZ3 functions as a transcriptional regulator that is involved in developmental processes throughout the body. The gene encoding TSHZ3 maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognised for having the greatest gene density of the human chromosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8145R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8145R-CY5.5
Lokale Artikelnummer::
BOSSBS-8145R-CY5.5
Beschreibung:
CHCHD5 is a 110 amino acid protein that contains one CHCH domain. The gene encoding CHCHD5 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstré°‰ syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11253R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11253R-CY5
Lokale Artikelnummer::
BOSSBS-11253R-CY5
Beschreibung:
PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9918R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9918R-A680
Lokale Artikelnummer::
BOSSBS-9918R-A680
Beschreibung:
SLURP1, also known as MDM, ARS, ANUP (anti-neoplastic urinary protein), LY6LS or ArsB (ARS component B), is a 103 amino acid secreted protein that exists as a homodimer possessing antitumour activity. Found in esophagus, stomach, exocervix, gums, urine, sweat, saliva, plasma and tears, SLURP1 is most highly expressed in the acrosyringium of the granular layer of skin, where it helps maintain the structure of the keratinocyte layers of the skin. Also considered a marker for late skin differentiation, SLURP1 contains one UPAR/Ly6 domain and is the cause of an autosomal recessive disorder of the skin known as Mal de Meleda (MDM). MDM Is characterised by nail abnormalities, keratotic skin lesions, transgressive palmoplantar keratoderma (PPK), perioral erythema and may sometimes include hyperhidrosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12215R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12215R-CY7
Lokale Artikelnummer::
BOSSBS-12215R-CY7
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF266 is a 549 amino acid nuclear protein belonging to the Krüppel C2H2-type zinc finger protein family. ZNF266 has one KRAB domain and fourteen C2H2 zinc fingers. Due to the presence of these domains, ZNF266 is thought to be involved in transcriptional regulation. Repression of ZNF266 results in the blocking of erythroid differentiation and partial blocking of megakaryocytic differentiation, possibly indicating a role in the differentiation of erythroids and megakaryocytes.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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