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Tetramethylthiurammonosulfid
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Tetramethylthiurammonosulfid
Artikel-Nr:
(BOSSBS-13544R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13544R-A555
Lokale Artikelnummer::
BOSSBS-13544R-A555
Beschreibung:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Bei der Entwicklung von Dauerpräparaten zur langfristigen Lagerung von Proben sollten wasserfreie Eindeckmittel, wie z. B. Neo-Mount®, verwendet werden. In pathologischen Laboren verarbeitete Objektträger müssen bis zu 10 Jahre gelagert werden, wobei die Anforderung besteht, dass die Färbeergebnisse stabil bleiben und kein Ausbleichen stattfindet. Neo-Mount®, ein wasserfreies Eindeckmittel für die Mikroskopie, ist äußerst farbstabil, was durch Lösungsmittel auf Basis von Mischungen aliphatischer Kohlenwasserstoffe erzielt wird. Es enthält ein aromaten-freies Ersatzmittel für Xylol, weshalb Neo-Mount® ausschließlich in Kombination mit Neo-Clear® verwendet werden darf. Bei der Eindeckung ist die Anwendung von Xylol zu vermeiden, da es die Objektträger eintrüben und Streifen verursachen kann. Da unter dem Deckglas Luftblasen entstehen könnten, sollten die dehydrierten Objektträger für ca. 1 Minute vor dem Eindecken auf Filterpapier abgelegt werden, um so eine Überschuss von Neo-Clear® zu verhindern. Die gleiche Vorkonditionierung sollte ebenfalls bei der Eindeckung von Proben mithilfe von Eindeckautomaten angewendet werden. In diesem Bereich lässt sich NEO-CLEAR® am effizientesten durch Inkubation der Objektträger für eine Minute in einem leeren Objektträger-Rack eliminieren.
Artikel-Nr:
(BOSSBS-13148R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13148R
Lokale Artikelnummer::
BOSSBS-13148R
Beschreibung:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. A wide range of enzymes facilitate in the proteolytic Ub pathway, including monoclonal nonspecific suppressor factor-beta (MNSF-beta), a subunit of MNSF, which is a lymphokine product of a murine T cell hybrid-oma that restricts the production of LPS-induced immunoglobulin secreting cells in an antigen-nonspecific manner. MNSF-beta is a ubiquitin-like fusion protein consisting of the ribosomal protein S30 and a protein that shares 36% sequence identity with ubiquitin. This ubiquitin-like segment (Ubi-L) can be cleaved from MNSF-beta in the cytosol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2676R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2676R-CY5
Lokale Artikelnummer::
BOSSBS-2676R-CY5
Beschreibung:
Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2676R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2676R-A488
Lokale Artikelnummer::
BOSSBS-2676R-A488
Beschreibung:
Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13684R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13684R-CY3
Lokale Artikelnummer::
BOSSBS-13684R-CY3
Beschreibung:
The Src homology 3 (SH3) domain is a highly conserved 60 amino acid protein domain that is organized into a beta-barrel fold consisting of five or six beta strands arranged as two tightly packed anti-parallel beta sheets. This domain is found in proteins that mediate assembly of specific protein complexes and interact with other proteins, specifically recognizing proline-rich regions. BAIAP2L2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) is a 529 amino acid protein containing an SH3 domain, suggesting that it may function as an adaptor protein. BAIAP2L2 also contains an IMD (IRSp53/MIM) domain, which enables the protein to bind to and bundle Actin filaments, as well as bind to membranes and interact with Rac GTPase. There are two named isoforms of BAIAP2L2 which are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13684R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13684R-CY7
Lokale Artikelnummer::
BOSSBS-13684R-CY7
Beschreibung:
The Src homology 3 (SH3) domain is a highly conserved 60 amino acid protein domain that is organized into a beta-barrel fold consisting of five or six beta strands arranged as two tightly packed anti-parallel beta sheets. This domain is found in proteins that mediate assembly of specific protein complexes and interact with other proteins, specifically recognizing proline-rich regions. BAIAP2L2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) is a 529 amino acid protein containing an SH3 domain, suggesting that it may function as an adaptor protein. BAIAP2L2 also contains an IMD (IRSp53/MIM) domain, which enables the protein to bind to and bundle Actin filaments, as well as bind to membranes and interact with Rac GTPase. There are two named isoforms of BAIAP2L2 which are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1912R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1912R-CY7
Lokale Artikelnummer::
BOSSBS-1912R-CY7
Beschreibung:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.
VE:
1 * 100 µl
Artikel-Nr:
(USBI128423)
Lieferant:
US Biological
Hersteller-Artikelnummer::
128423
Lokale Artikelnummer::
USBI128423
Beschreibung:
Anti-IL1B Mouse Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-0711R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0711R
Lokale Artikelnummer::
BOSSBS-0711R
Beschreibung:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11179R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11179R
Lokale Artikelnummer::
BOSSBS-11179R
Beschreibung:
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5457R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5457R-A680
Lokale Artikelnummer::
BOSSBS-5457R-A680
Beschreibung:
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1163R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1163R-CY3
Lokale Artikelnummer::
BOSSBS-1163R-CY3
Beschreibung:
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. The mature form of Beta defensin 1 is 36 amino acids.
VE:
1 * 100 µl
Artikel-Nr:
(P001)
Lieferant:
G-Biosciences
Hersteller-Artikelnummer::
P001
Lokale Artikelnummer::
GENOP001
Beschreibung:
Mercaptoethanol
VE:
1 * 5 mL
Artikel-Nr:
(USBI128518)
Lieferant:
US Biological
Hersteller-Artikelnummer::
128518
Lokale Artikelnummer::
USBI128518
Beschreibung:
Anti-INHBE Rabbit Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-12543R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12543R
Lokale Artikelnummer::
BOSSBS-12543R
Beschreibung:
ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6beta homodimer or an ATF-6Alpha/beta heterodimer. Binding of the ATF-6beta homodimer or ATF-6Alpha/beta heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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