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5-Chlorobenzo[b]thiophene-3-acetic+acid
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5-Chlorobenzo[b]thiophene-3-acetic+acid
Lieferant:
Alfa Aesar
Beschreibung:
Lidocain Hydrochlorid Monohydrat ≥98%
Artikel-Nr:
(BOSSBS-2734R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2734R-CY5.5
Lokale Artikelnummer::
BOSSBS-2734R-CY5.5
Beschreibung:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2734R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2734R-HRP
Lokale Artikelnummer::
BOSSBS-2734R-HRP
Beschreibung:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
2-Adamantylamin Hydrochlorid, Sigma-Aldrich®
Lieferant:
MP Biomedicals
Beschreibung:
AEBSF hydrochloride is a covalent binding serine protease inhibitor, belongs to the family of irreversible sulphonyl fluoride inhibitors that block trypsin and chymotrypsin-type enzymes.
Lieferant:
COMBI-BLOCKS
Beschreibung:
2-Amino-4'-(dimethylamino)acetophenon Hydrochlorid
Artikel-Nr:
(SIAL419974-250MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
419974-250MG
Lokale Artikelnummer::
SIAL419974-250MG
Beschreibung:
4'-Formylbenzo-15-krone-5 (4'-Formylbenzo-1,4,7,10,13-pentaoxacyclopentadecan), Sigma-Aldrich®
VE:
1 * 250 mg
Artikel-Nr:
(EHERYA13223000ME)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
YA13223000ME
Lokale Artikelnummer::
EHERYA13223000ME
Beschreibung:
Organic Standard, Ethanol absolut 2.000 µg/ml in Methanol, Packung: Glasflasche
VE:
1 * 1 mL
Lieferant:
COMBI-BLOCKS
Beschreibung:
2,6-Dimethoxyanilin Hydrochlorid
Lieferant:
Thermo Scientific
Beschreibung:
2,6-Dibrom-4-chloranilin
Artikel-Nr:
(MOLEM40463419)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M40463419
Lokale Artikelnummer::
MOLEM40463419
Beschreibung:
(S)-(+)-1-Amino-2-propanol
VE:
1 * 5 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
COMBI-BLOCKS
Beschreibung:
3-(4-Methyl-1-piperazinylcarbonyl)phenylboronsäure Hydrochlorid
Lieferant:
COMBI-BLOCKS
Beschreibung:
N-Methyl-2-brom-5-fluoranilin Hydrochlorid
Artikel-Nr:
(BOSSBS-1380R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1380R-A555
Lokale Artikelnummer::
BOSSBS-1380R-A555
Beschreibung:
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilisation and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(17-5181-01)
Lieferant:
Cytiva
Hersteller-Artikelnummer::
17-5181-01
Lokale Artikelnummer::
GEHE17-5181-01
Beschreibung:
SOURCE™ 15Q PE is a strong anion exchanger prepacked in a tricorn column for intermediate lab-scale purification and large-scale polishing of biomolecules with ion exchange chromatography.
VE:
1 * 1 ST
Lieferant:
COMBI-BLOCKS
Beschreibung:
4-Brom-N-methylanilin Hydrochlorid
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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