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2\'-Fluorpropiophenon
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2\'-Fluorpropiophenon
Artikel-Nr:
(BOSSBS-8161R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8161R-A350
Lokale Artikelnummer::
BOSSBS-8161R-A350
Beschreibung:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2358R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2358R-FITC
Lokale Artikelnummer::
BOSSBS-2358R-FITC
Beschreibung:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13180R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13180R-CY7
Lokale Artikelnummer::
BOSSBS-13180R-CY7
Beschreibung:
Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes. The FLJ11184 gene product has been provisionally designated FLJ11184 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5835R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5835R-CY5
Lokale Artikelnummer::
BOSSBS-5835R-CY5
Beschreibung:
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3013R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3013R-CY5.5
Lokale Artikelnummer::
BOSSBS-3013R-CY5.5
Beschreibung:
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6026R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6026R-A350
Lokale Artikelnummer::
BOSSBS-6026R-A350
Beschreibung:
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6743R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6743R-CY5
Lokale Artikelnummer::
BOSSBS-6743R-CY5
Beschreibung:
TPD54
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8155R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8155R-A350
Lokale Artikelnummer::
BOSSBS-8155R-A350
Beschreibung:
Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6299R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6299R-A555
Lokale Artikelnummer::
BOSSBS-6299R-A555
Beschreibung:
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12320R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12320R-HRP
Lokale Artikelnummer::
BOSSBS-12320R-HRP
Beschreibung:
Defects in TCTN2 are the cause of Meckel syndrome type 8 (MKS8) [MIM:613885]. A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9720R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9720R-CY5.5
Lokale Artikelnummer::
BOSSBS-9720R-CY5.5
Beschreibung:
C10orf27, also known as spatial, is a 351 amino acid cytoplasmic protein belonging to the spatial family. C10orf27 is suggested to play a role in spermatid differentiation. Existing as two alternatively spliced isoforms, C10orf27 is widely expressed in multiple tissues, including brain, thymus and testis. C10orf27 may be associated with multiple sclerosis (MS) susceptibility and pathogenesis. MS is an inflammatory disease that causes gradual destruction of myelin in the central nervous system. C10orf27 is encoded by a gene located on human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7886R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7886R-CY5
Lokale Artikelnummer::
BOSSBS-7886R-CY5
Beschreibung:
May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8193R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8193R-CY5
Lokale Artikelnummer::
BOSSBS-8193R-CY5
Beschreibung:
Tumor-associated antigen.Tissue specificity:Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6304R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6304R-CY5
Lokale Artikelnummer::
BOSSBS-6304R-CY5
Beschreibung:
Produced by macrophages, IFN alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5060R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5060R-CY7
Lokale Artikelnummer::
BOSSBS-5060R-CY7
Beschreibung:
FADS1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids, linoleic acid and alphanlinolenic acid. It catalyzes the desaturation of dihomo gamma linoleic acid and eicosatetraenoic acid to generate arachidonic acid and eicosapentaenoic acid respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13688R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13688R-A647
Lokale Artikelnummer::
BOSSBS-13688R-A647
Beschreibung:
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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