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Tris(pentafluorphenyl)boran
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Tris(pentafluorphenyl)boran
Artikel-Nr:
(BOSSBS-15211R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15211R-CY5
Lokale Artikelnummer::
BOSSBS-15211R-CY5
Beschreibung:
C5orf55
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15164R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15164R-A680
Lokale Artikelnummer::
BOSSBS-15164R-A680
Beschreibung:
C3IP1
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11306R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11306R-A680
Lokale Artikelnummer::
BOSSBS-11306R-A680
Beschreibung:
Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation. The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear. The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A). In cultured eukaryotic cells, this enzyme is essential for survival. The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association. There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin. Expressed CCT A has lipid-dependent cytidylyltransferase activity. The gene which encodes CCT A maps to human chromosome 3q.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9663R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9663R-A750
Lokale Artikelnummer::
BOSSBS-9663R-A750
Beschreibung:
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt Signalling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localisation. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9563R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9563R-A750
Lokale Artikelnummer::
BOSSBS-9563R-A750
Beschreibung:
LMBR1 is a 490 amino acid multi-pass membrane protein that is widely expressed with strongest expression in heart and pancreas. Belonging to the LIMR family, LMBR1 shares 95% sequence identity with the mouse protein and may play crucial role in the evolution of limb and skeletal system. LMBR1 is critical for expression of sonic hedgehog (Shh) in the developing posterior limb bud mesenchyme. Mutations in the gene encoding LMBR1 is the cause of several rare conditions such as acheiropody (ACHP) and syndactyly type 4 (SDYT4). ACHP is an autosomal recessive inherited disorder characterised by bilateral congenital amputations of the hands and feet. LMBR1L (limb region 1 protein homolog-like), also known as LIMR (Lipocalin-1-interacting membrane receptor), is a 489 amino acid multi-pass membrane protein that is thought to act as a receptor for Lipocalin-1 and may also assist in its endocytosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10126R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10126R-A750
Lokale Artikelnummer::
BOSSBS-10126R-A750
Beschreibung:
Linker for activation of T cells (LAT) is an integral membrane protein (36 to 38 kD), which plays an important role in linking engagement of the TCR to the biochemical events of T cell activation. LAT antibody stains thymus and peripheral lymphoid tissues such as T cell areas in lymph nodes and spleen. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes. LAT is not expressed in B cells, macrophages, plasma cells, monocytes, epithelial histiocytes and dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11012R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11012R-A680
Lokale Artikelnummer::
BOSSBS-11012R-A680
Beschreibung:
Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. The FAM98 gene product has been provisionally designated FAM98 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11001R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11001R-A750
Lokale Artikelnummer::
BOSSBS-11001R-A750
Beschreibung:
May play a role in control of mRNA translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10751R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10751R-A750
Lokale Artikelnummer::
BOSSBS-10751R-A750
Beschreibung:
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2643R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2643R-A680
Lokale Artikelnummer::
BOSSBS-2643R-A680
Beschreibung:
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2907R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2907R-A680
Lokale Artikelnummer::
BOSSBS-2907R-A680
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilising MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3964R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3964R-A350
Lokale Artikelnummer::
BOSSBS-3964R-A350
Beschreibung:
PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11847R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11847R-HRP
Lokale Artikelnummer::
BOSSBS-11847R-HRP
Beschreibung:
GPM6B belongs to the myelin proteolipid protein family and is implicated in neural development. It is expressed in neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7976R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7976R-FITC
Lokale Artikelnummer::
BOSSBS-7976R-FITC
Beschreibung:
The exact functions of ATXN7L2 remain unknown.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6908R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6908R-HRP
Lokale Artikelnummer::
BOSSBS-6908R-HRP
Beschreibung:
HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15021R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15021R
Lokale Artikelnummer::
BOSSBS-15021R
Beschreibung:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf141 gene product has been provisionally designated C1orf141 pending further characterization.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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