Suche >
Ethyl-2-naphthoyl+formate
Drucken
Sie suchten nach:
35 990 results were found
Ethyl-2-naphthoyl+formate
Artikel-Nr:
(BOSSBS-11730R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11730R-A750
Lokale Artikelnummer::
BOSSBS-11730R-A750
Beschreibung:
Voltage-gated K+ channels in the plasma membrane control the repolarisation and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1790R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1790R-CY3
Lokale Artikelnummer::
BOSSBS-1790R-CY3
Beschreibung:
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13670R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13670R-CY3
Lokale Artikelnummer::
BOSSBS-13670R-CY3
Beschreibung:
Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1071R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1071R-CY5.5
Lokale Artikelnummer::
BOSSBS-1071R-CY5.5
Beschreibung:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1071R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1071R-CY3
Lokale Artikelnummer::
BOSSBS-1071R-CY3
Beschreibung:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13703R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13703R
Lokale Artikelnummer::
BOSSBS-13703R
Beschreibung:
The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD00835440-50M)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD00835440-50M
Lokale Artikelnummer::
BLDPBD00835440-50M
Beschreibung:
rel-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate 95%
VE:
1 * 50 mg
Artikel-Nr:
(APOSPC410488-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC410488-1G
Lokale Artikelnummer::
APOSPC410488-1G
Beschreibung:
[3-Cyclopropyl-4-(difluoromethyl)-6-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
VE:
1 * 1 g
Lieferant:
Merck
Beschreibung:
Diethyloxalat zur Synthese, Sigma-Aldrich®
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2,5,8-Trimethyl-3-chinolincarbonsäureethylester
Lieferant:
VWR Chemicals
Beschreibung:
Ethanol 20% BiopharmaceuticalProduction
Artikel-Nr:
(39337-10MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
39337-10MG
Lokale Artikelnummer::
SUPL39337-10MG
Beschreibung:
Sethoxydim ist ein selektives systemisches Cyclohexandionoxim-Herbizid, das hauptsächlich durch das Laub und in geringerem Maße durch die Wurzeln absorbiert wird. Es handelt sich um einen Inhibitor der Acetyl-CoA-Carboxylase (ACCase), der den Einbau von Acetat in Fettsäuren hemmt und die Bildung von Phospholipiden stört, die zum Aufbau neuer Membranen verwendet werden. Es wird zur Bekämpfung ein- und mehrjähriger Ungräser (außer <i>Poa spp.</i>) in breitblättrigen Nutzpflanzen wie Baumwolle, Raps, Sojabohnen, Zuckerrüben, Futterrüben, Sonnenblumen, Spinat, Kartoffeln, Tabak, Erdnüssen, Erdbeeren, Luzerne, Flachs und Gemüse eingesetzt. Sethoxydim ist gemäß der Verordnung (EG) Nr. 1107/2009 zur Aufhebung der Richtlinie 91/414/EWG nicht zur Verwendung als Pflanzenschutzmittel in der Europäischen Union (EU) zugelassen. Für das Vorhandensein von Sethoxydim, ausgedrückt als Summe von Sethoxydim und Clethodim einschließlich ihrer Abbauprodukte, sind jedoch gemäß der EU-Verordnung Nr. 839/2008 maximale Rückstandsmengen von 0,05 bis 10 mg/kg in Produkten pflanzlichen und tierischen Ursprungs zulässig.
VE:
1 * 10 mg
Artikel-Nr:
(BOSSBS-3088R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3088R-A750
Lokale Artikelnummer::
BOSSBS-3088R-A750
Beschreibung:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12350R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12350R-A680
Lokale Artikelnummer::
BOSSBS-12350R-A680
Beschreibung:
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and in the control of gene expression. MIXL1 (Mix1 homeobox-like 1), also known as MIXL, is a 232 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in lymph tissues, MIXL1 functions as a transcription factor that plays an essential role in axial mesendoderm morphogenesis and endoderm formation and is also required for cellular differentiation during blood development. Additionally, MIXL1 is involved in maturation of heart and gut tissue during embryogenesis and may also act as a negative regulator of brachyury expression. Overexpression of MIXL1 is associated with non-Hodgkin and Hodgkin lymphomas, suggesting a role in carcinogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9376R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9376R-A555
Lokale Artikelnummer::
BOSSBS-9376R-A555
Beschreibung:
MuRF1, is a nuclear protein that interacts with SMT3b and the large myofibrillar protein Titin. In muscle cells, MuRF2 (RFN29) regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including Titin and Myosin. MuRF3, also designated tripartite motif-containing 54 (TRIM54) or ring finger protein 30 (RNF30), interacts with tubulin and stabilizes microtubules duing myotube formation. It is a cytoplasmic protein the localizes to the Z-lines in skeletal muscles, while MuRF2 localizes to the sarcomeric M-band in cardiomyocytes. MuRF3 shares 77% and 65% sequence identity with MuRF1 and MuRF2, respectively. MuRF1-3 share a conserved N-terminal RING domain and zinc-binding B-box motif, and two coiled-coil dimerization motif boxes, in their central regions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9376R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9376R-HRP
Lokale Artikelnummer::
BOSSBS-9376R-HRP
Beschreibung:
MuRF1, is a nuclear protein that interacts with SMT3b and the large myofibrillar protein Titin. In muscle cells, MuRF2 (RFN29) regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including Titin and Myosin. MuRF3, also designated tripartite motif-containing 54 (TRIM54) or ring finger protein 30 (RNF30), interacts with tubulin and stabilizes microtubules duing myotube formation. It is a cytoplasmic protein the localizes to the Z-lines in skeletal muscles, while MuRF2 localizes to the sarcomeric M-band in cardiomyocytes. MuRF3 shares 77% and 65% sequence identity with MuRF1 and MuRF2, respectively. MuRF1-3 share a conserved N-terminal RING domain and zinc-binding B-box motif, and two coiled-coil dimerization motif boxes, in their central regions.
VE:
1 * 100 µl
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
