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BIOSS INC
Artikel-Nr:
(BOSSBS-7135R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7135R-CY3
Lokale Artikelnummer::
BOSSBS-7135R-CY3
Beschreibung:
MAZ
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3251R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3251R-FITC
Lokale Artikelnummer::
BOSSBS-3251R-FITC
Beschreibung:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0505R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0505R-CY5
Lokale Artikelnummer::
BOSSBS-0505R-CY5
Beschreibung:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7877R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7877R
Lokale Artikelnummer::
BOSSBS-7877R
Beschreibung:
Anti-NEDD4 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1896R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1896R
Lokale Artikelnummer::
BOSSBS-1896R
Beschreibung:
Anti-SOCS2 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12181R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12181R
Lokale Artikelnummer::
BOSSBS-12181R
Beschreibung:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1726R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1726R-A555
Lokale Artikelnummer::
BOSSBS-1726R-A555
Beschreibung:
Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9196R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9196R-HRP
Lokale Artikelnummer::
BOSSBS-9196R-HRP
Beschreibung:
IGSF3, also known as V8 or EWI-3, is a 1,214 amino acid protein. Widely expressed with predominant expression in kidney, placenta and lung, IGSF3 localizes to the membrane and contains an N-terminal signal peptide, eight immunoglobulin (Ig) domains and a transmembrane segment. IGSF3 exhibits strong sequence and structural similarity to CD101 (32% identity), a leukocyte surface protein with seven Ig domains that is believed to play a role in T-cell activation. Despite the structural similarities between IGSF3 and CD101, IGSF3 is not expressed in peripheral blood lymphocytes and does not appear to participate in an immune function. Based on its subcellular localization and the presence of the eight Ig domains, IGSF3 is hypothesized to function as a surface receptor or as a cell adhesion molecule.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5156R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5156R-CY7
Lokale Artikelnummer::
BOSSBS-5156R-CY7
Beschreibung:
May play a role in mediating neutrophil activation and chemotaxis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3929R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3929R-A680
Lokale Artikelnummer::
BOSSBS-3929R-A680
Beschreibung:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyses the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15119R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15119R-CY5
Lokale Artikelnummer::
BOSSBS-15119R-CY5
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf94 gene product has been provisionally designated C20orf94 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12473R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12473R-HRP
Lokale Artikelnummer::
BOSSBS-12473R-HRP
Beschreibung:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11515R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11515R-HRP
Lokale Artikelnummer::
BOSSBS-11515R-HRP
Beschreibung:
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. CD39 inhibits ADP-induced platelet aggregation by hydrolyzing ADP to AMP and ultimately generating adenosine. Intracellular CD39 undergoes glycosylation at 6 N-glycosylation sites and translocates to the membrane in order to be an active enzyme. CD39L1 is a 495 amino acid multi-pass membrane protein that requires calcium and magnesium cofactors to hydrolyze ATP and other nucleotides in the regulation of purigenic neurotransmission. CD39L1 is expressed in kidney, colon, heart, testis, pancreas, brain, prostate, skeletal muscle, small intestine and ovaries. There are two isoforms of CD39L1 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3055R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3055R-CY3
Lokale Artikelnummer::
BOSSBS-3055R-CY3
Beschreibung:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7108R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7108R-CY5
Lokale Artikelnummer::
BOSSBS-7108R-CY5
Beschreibung:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3577R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3577R-CY3
Lokale Artikelnummer::
BOSSBS-3577R-CY3
Beschreibung:
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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