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BIOSS INC
Artikel-Nr:
(BOSSBS-12261R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12261R
Lokale Artikelnummer::
BOSSBS-12261R
Beschreibung:
RTF1 is the the major histocompatibility complex (MHC) in the rat which contains genes that code for two class II histocompatibility antigens. RT1-B is an antigen of the RT1 complex. It is a protein dimer consisting of an alpha and beta glycoprotein chain and is homologous to I-A and I-E genes, respectively, in the H-2 complex of the mouse. MHC Class II antigens are useful in studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these also stain stromal cells in the thymus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7335R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7335R-FITC
Lokale Artikelnummer::
BOSSBS-7335R-FITC
Beschreibung:
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3614R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3614R-A555
Lokale Artikelnummer::
BOSSBS-3614R-A555
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12261R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12261R-A350
Lokale Artikelnummer::
BOSSBS-12261R-A350
Beschreibung:
RTF1 is the the major histocompatibility complex (MHC) in the rat which contains genes that code for two class II histocompatibility antigens. RT1-B is an antigen of the RT1 complex. It is a protein dimer consisting of an alpha and beta glycoprotein chain and is homologous to I-A and I-E genes, respectively, in the H-2 complex of the mouse. MHC Class II antigens are useful in studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these also stain stromal cells in the thymus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7335R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7335R-A488
Lokale Artikelnummer::
BOSSBS-7335R-A488
Beschreibung:
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6866R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6866R
Lokale Artikelnummer::
BOSSBS-6866R
Beschreibung:
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4055R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4055R-A647
Lokale Artikelnummer::
BOSSBS-4055R-A647
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13021R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13021R-A750
Lokale Artikelnummer::
BOSSBS-13021R-A750
Beschreibung:
DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13021R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13021R-A680
Lokale Artikelnummer::
BOSSBS-13021R-A680
Beschreibung:
DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5045R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5045R-A750
Lokale Artikelnummer::
BOSSBS-5045R-A750
Beschreibung:
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-18539R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-18539R-A750
Lokale Artikelnummer::
BOSSBS-18539R-A750
Beschreibung:
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3818R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3818R-A750
Lokale Artikelnummer::
BOSSBS-3818R-A750
Beschreibung:
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterised by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7626R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7626R-A555
Lokale Artikelnummer::
BOSSBS-7626R-A555
Beschreibung:
RelevanceHAX1 associates with HS1, binding to its N-terminal region. It is also known to associate with PKD2 (involved in polycystic kidney disease) and with cortactin/EMS1. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6715R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6715R-FITC
Lokale Artikelnummer::
BOSSBS-6715R-FITC
Beschreibung:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10490R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10490R-A350
Lokale Artikelnummer::
BOSSBS-10490R-A350
Beschreibung:
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7626R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7626R-HRP
Lokale Artikelnummer::
BOSSBS-7626R-HRP
Beschreibung:
RelevanceHAX1 associates with HS1, binding to its N-terminal region. It is also known to associate with PKD2 (involved in polycystic kidney disease) and with cortactin/EMS1. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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